Andrew Shorthouse

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Over-expression and abnormal intracellular location of the product of the oncogene c-myc in colonic dysplasia and neoplasia may be related to alterations in epigenetic mechanisms controlling the functioning of this gene. We have investigated the methylation patterns of the c-myc oncogene in human colorectal tissue representing various stages of dysplasia(More)
BACKGROUND Lateral spreading tumours are superficial spreading neoplasms now increasingly diagnosed using chromoscopic colonoscopy. The clinicopathological features and safety of endoscopic mucosal resection for lateral spreading tumours (G-type "aggregate" and F-type "flat") has yet to be clarified in Western cohorts. METHODS Eighty two patients(More)
A series of human bronchial-carcinoma xenografts (3 small-cell anaplastic, 2 large-cell anaplastic and 3 adenocarcinomas) established in immune-suppressed mice were treated with combination chemotherapy based on clinical regimes. Xenograft response was assessed by the in situ endpoint of growth delay in s.c. tumours. Dose-response relationships of 3(More)
The effect of melphalan on the growth of 4 different lines of human lung-tumour xenografts has been established. The oat-cell carcinoma was the most sensitive, whereas the adenocarcinoma was the most resistant. Two lines of large-cell anaplastic carcinomas were intermediate in sensitivity. The differences in sensitivity were not reflected in the gross(More)
THE ABILITY of a series of human lung carcinoma xenografts to predict clinical response to cytotoxic drugs was demonstrated by Shorthouse et al. (1980) when tumour biopsy samples from patients with lung cancer were established as xenografts in immune-suppressed mice and the drug combinations used to treat the patients were also administered to the(More)
Following the demonstration by Rygaard and Povlsen (1969) that human tumours could be grown in congenitally athymic mice and the subsequent use of thymectomised, whole-body irradiated mice suitable for tumour heterotransplantation (Castro, 1972), large numbers of serially transplantable human tumour xenograft lines have been established (Shimosato et al.,(More)
BACKGROUND Advanced age is associated with a reduction in clinical visceral pain perception. However, the underlying mechanisms remain largely unknown. Previous studies have suggested that an abnormal interplay between mast cells, enterochromaffin (EC) cells, and afferent nerves contribute to nociception in gastrointestinal disorders. The aim of this study(More)
Colorectal cancer remains a leading cause of cancer death in the UK. With the advent of screening programmes and developing techniques designed to treat and stage colorectal neoplasia, there is increasing pressure on the colonoscopist to keep up to date with the latest practices in this area. This review looks at the basic principles behind endoscopic(More)