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BACKGROUND High magnification chromoscopic colonoscopy (HMCC) permits the in vivo examination of the colorectal pit pattern, which has a high correlation with stereomicroscopic appearances of resected specimens. This new technology may provide an "optical biopsy" which can be used to aid diagnostic precision and guide therapeutic strategies. Conflicting(More)
BACKGROUND A transverse skin crease incision for right hemicolectomy may result in more rapid recovery than traditional vertical midline incision. This hypothesis was tested with a prospective randomised trial. METHODS Patients from 2 centres undergoing right hemicolectomy were randomised to received a midline or transverse incision. Incision lengths were(More)
OBJECTIVE A prospective technical feasibility study of cap assisted ESD for 'curative intent' in patients with residual or local neoplastic recurrence following EMR. Primary end points were second stage R0 resection rate, safety and recurrence. METHOD Salvage ESD was performed using the Olympus GIF-XQ240 gastroscope and KD-630L insulation tipped knife.(More)
AIM The objective of the study was to assess safety, efficacy and outcomes of stapled transanal rectal resection (STARR) procedure for obstructed defaecation syndrome (ODS) with two stapling devices, PPH01 and Trans-STARR. METHOD Data were collected on all patients undergoing PPH01 or Trans-STARR over a 2 year period. Initially, all were treated using the(More)
OBJECTIVE To investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes. DESIGN A prospective, randomized, controlled pilot trial. SETTING University rehabilitation facility. PARTICIPANTS(More)
BACKGROUND Lateral spreading tumours are superficial spreading neoplasms now increasingly diagnosed using chromoscopic colonoscopy. The clinicopathological features and safety of endoscopic mucosal resection for lateral spreading tumours (G-type "aggregate" and F-type "flat") has yet to be clarified in Western cohorts. METHODS Eighty two patients(More)
OBJECTIVES Flat and depressed colorectal lesions are now reported in Western populations. The malignant potential, anatomical distribution, and other clinicopathological features have not been established in this group. This study aimed to assess prospectively the prevalence, clinicopathological, and endoscopic features of flat and depressed colorectal(More)
BACKGROUND No standardized approach is available for the management of complicated appendicitis defined as appendiceal abscess and phlegmon. This study used meta-analytic techniques to compare conservative treatment versus acute appendectomy. METHODS Comparative studies were identified by a literature search. The end points evaluated were overall(More)
BACKGROUND Mortality associated with human breast carcinoma is almost entirely due to subsequent metastatic disease, but the molecular basis of this metastasis is not understood. Elucidation of the genetic control of metastatic propensity of a tumor is important in determining prognosis and choice of therapy. Expression of nm23, a putative metastasis(More)