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The influenza A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) virus was evaluated as a donor of attenuating genes to new variants of influenza A virus. This ca donor virus was mated with the A/Alaska/6/77 (H3N2) wild-type virus, and three A/Alaska/6/77 (H3N2) ca recombinant viruses were produced. The parental origin of the genes in the three ca recombinants had(More)
A case initially thought to be ameloblastoma of the mandible which showed rapid local destruction and was demonstrated to have three pulmonary metastases post mortem 18 months after the first symptoms in the mandible. The diagnosis is now considered to be ameloblastic carcinoma. The difficulties in histological diagnosis and varying classifications of(More)
A case of malignant calcifying epithelial odontogenic tumour is reported in a 75-year-old man. Evidence of local tissue invasion and lymph-node metastasis is presented. Immunoperoxidase studies of the neoplastic cells and tumour amyloid were negative for a variety of antigens, including the epithelial markers CEA and keratin. The histological and clinical(More)
BACKGROUND Mutations of TCF4, which encodes a basic helix-loop-helix transcription factor, cause Pitt-Hopkins syndrome (PTHS) via multiple genetic mechanisms. TCF4 is a complex locus expressing multiple transcripts by alternative splicing and use of multiple promoters. To address the relationship between mutation of these transcripts and phenotype, we(More)
  • A J Sear
  • 1977
A method of intra-nasal splinting has been outlined which revives principles and improves on methods established particularly well by two French Stomatologists at the beginning of this century. It uses a simple splint, carefully chosen from a range of sizes, that requires precise insertion, and has proved to have several advantages over more commonly(More)
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