Andrew S. Gibbons

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Autophagy has a key role in the pathophysiology of schizophrenia

Avia Merenlender-Wagner, Anna Malishkevich, +7 authors Illana Gozes
Molecular Psychiatry
2015

Autophagy is a process preserving the balance between synthesis, degradation and recycling of cellular components and is therefore essential for neuronal survival and function. Several key proteins… (More)

Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders

Brian Dean, Andrew S. Gibbons, Nahed Tawadros, Lucy J Brooks, Ian Everall, Elizabeth Scarr
Molecular Psychiatry
2013

The growing body of evidence implicating tumor necrosis factor-α (TNFα) in the pathophysiology of psychiatric disorders led us to measure levels of that protein in the cortex of subjects with major… (More)

Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects.

Andrew S. Gibbons, Elizabeth Scarr, Catriona A. McLean, Suresh Sundram, Brian Dean
Journal of affective disorders
2009

BACKGROUND Dysfunction of the cholinergic muscarinic receptors has been implicated in the pathology of bipolar disorder and major depressive disorder. However, there is conflicting evidence regarding… (More)

Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia.

Andrew S. Gibbons, Elizabeth Scarr, +4 authors Brian Dean
The international journal of…
2013

These studies were undertaken to investigate the selectivity of cortical muscarinic receptor radioligand binding in muscarinic M(1) and M(4) receptor knockout mice and to determine whether a marked… (More)

A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings

Andrea Gogos, Alyssa M. Sbisa, Jeehae Sun, Andrew S. Gibbons, Madhara Udawela, Brian Dean
International journal of endocrinology
2015

Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones… (More)

The use of a modified [<ce:sup loc=post>3</ce:sup>H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood…

Won Je Jeon, Andrew S. Gibbons, Brian Dean
Progress in Neuro-Psychopharmacology and…
2013

[(3)H]4-DAMP is a radioligand that has been used to quantify levels of the muscarinic receptor CHRM3 protein in situ. However, in addition to high affinity binding to CHRM3, [(3)H]4-DAMP binds with… (More)

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

Elizabeth Scarr, Jeffrey M Craig, +10 authors Brian Dean
Translational Psychiatry
2013

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be separated into two populations based on a marked loss of CHRM1… (More)

Design languages, notation systems, and instructional technology

Sandie H Waters, Andrew S. Gibbons
2003

Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder.

Brian Dean, Nahed Tawadros, Elizabeth Scarr, Andrew S. Gibbons
Journal of affective disorders
2010

BACKGROUND From studies in the periphery, changed levels of tumour necrosis factor (TNF) have been implicated in the pathophysiology of major depressive disorders (MDD). Therefore we decided to… (More)

Cholinergic connectivity: it's implications for psychiatric disorders

Elizabeth Scarr, Andrew S. Gibbons, Jaclyn H Neo, Madhara Udawela, Brian Dean
Front. Cell. Neurosci.
2013

Acetylcholine has been implicated in both the pathophysiology and treatment of a number of psychiatric disorders, with most of the data related to its role and therapeutic potential focusing on… (More)

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