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We report week 96 results from a phase 3 trial of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/COBI/FTC/TDF, n = 348) vs efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF, n = 352). At week 48, EVG/COBI/FTC/TDF was noninferior to EFV/FTC/TDF (88% vs 84%, difference +3.6%, 95% confidence interval: -1.6% to 8.8%).(More)
This ongoing, randomized, double-blind, active-controlled phase 3 international trial demonstrated the noninferior efficacy of elvitegravir/cobicistat/emtricitabine/tenofovir DF (EVG/COBI/FTC/TDF) compared with atazanavir boosted by ritonavir (ATV/RTV) plus emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) at 48 weeks. Here, we report the week 96(More)
Automatic Speech Recognition systems suffer from severe performance degradation in the presence of myriad complicating factors such as noise, reverberation, multiple speech sources, multiple recording devices, etc. Previous challenges have sparked much innovation when it comes to designing systems capable of handling these complications. In this spirit, the(More)
Let G = (V, E) be a graph. A set S ⊆ V is a restrained dominating set if every vertex not in S is adjacent to a vertex in S and to a vertex in V − S. The restrained domination number of G, denoted by γ r (G), is the smallest cardinality of a restrained dominating set of G. We define the restrained bondage number b r (G) of a nonempty graph G to be the(More)
Plummer [3] showed that categorial grammars based on NL S4 , the non-associative multimodal Lambek Calculus enriched with S4 axioms, weakly recognize context-free languages. However, the proof contains a gap. We correct the earlier proof, utilizing a technique given in Buszkowski [1]. This technique immediately proves that NL S4 is decidable in polynomial(More)
We present updates to the Speech Recognition Virtual Kitchen (SRVK) environment, a repository of pre-configured Virtual Machines (VMs) containing tools and experiments in the speech and language field. SRVK promotes community sharing of research techniques, fosters innovative experimentation, and provides solid reference systems as a tool for education,(More)
BACKGROUND Tenofovir disoproxil fumarate can cause renal and bone toxic effects related to high plasma tenofovir concentrations. Tenofovir alafenamide is a novel tenofovir prodrug with a 90% reduction in plasma tenofovir concentrations. Tenofovir alafenamide-containing regimens can have improved renal and bone safety compared with tenofovir disoproxil(More)
BACKGROUND Antiretroviral regimens containing tenofovir disoproxil fumarate have been associated with renal toxicity and reduced bone mineral density. Tenofovir alafenamide is a novel tenofovir prodrug that reduces tenofovir plasma concentrations by 90%, thereby decreasing off-target side-effects. We aimed to assess whether efficacy, safety, and(More)
—Traditionally the positioning of pneumatic actuators has been limited to movement between preset stops or switches. The restricting factors preventing the use of pneumatic cylinders for accurate servo-control arise from highly nonlinear dynamic properties such as air compressibility and friction effects, which combine to severely degrade time response and(More)