Andrew R Moffatt

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A number of innovations underlie the origin of rapid reproductive cycles in angiosperms. A critical early step involved the modification of an ancestrally short and slow-growing pollen tube for faster and longer distance transport of sperm to egg. Associated with this shift are the predominantly callose (1,3-β-glucan) walls and septae (callose plugs) of(More)
OBJECTIVE To examine the relationship between HIV protease genotype and altered protease inhibitor sensitivity of isolates from patients after therapy with saquinavir (SQV) in its hard gelatin formulation. DESIGN Forty-one post-therapy isolates and corresponding baseline samples were obtained from 37 patients in four different clinical trials after(More)
OBJECTIVES Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine (ddC), to determine the influence of such changes on viral phenotype and response to treatment. DESIGN Virologic substudies of Phase III clinical trials NV14256 and SV14604. METHODS Population(More)
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