Andrew R Moffatt

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OBJECTIVE To examine the relationship between HIV protease genotype and altered protease inhibitor sensitivity of isolates from patients after therapy with saquinavir (SQV) in its hard gelatin formulation. DESIGN Forty-one post-therapy isolates and corresponding baseline samples were obtained from 37 patients in four different clinical trials after(More)
BACKGROUND A number of innovations underlie the origin of rapid reproductive cycles in angiosperms. A critical early step involved the modification of an ancestrally short and slow-growing pollen tube for faster and longer distance transport of sperm to egg. Associated with this shift are the predominantly callose (1,3-β-glucan) walls and septae (callose(More)
OBJECTIVES Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine (ddC), to determine the influence of such changes on viral phenotype and response to treatment. DESIGN Virologic substudies of Phase III clinical trials NV14256 and SV14604. METHODS Population(More)
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