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Multiphoton microscopy of collagen hydrogels produces second harmonic generation (SHG) and two-photon fluorescence (TPF) images, which can be used to noninvasively study gel microstructure at depth ( approximately 1 mm). The microstructure is also a primary determinate of the mechanical properties of the gel; thus, we hypothesized that bulk optical(More)
Datacenter workloads demand high computational capabilities, flexibility, power efficiency, and low cost. It is challenging to improve all of these factors simultaneously. To advance datacenter capabilities beyond what commodity server designs can provide, we designed and built a composable, reconfigurable hardware fabric based on field programmable gate(More)
Silicon technology will continue to provide an exponential increase in the availability of raw transistors. Effectively translating this resource into application performance, however, is an open challenge that conventional superscalar designs will not be able to meet. We present WaveScalar as a scalable alternative to conventional designs. WaveScalar is a(More)
Angiogenesis, the sprouting of new blood vessels from existing vasculature, is a complex biological process of interest to both the treatment of numerous pathologies and the creation of thick engineered tissues. In the context of tissue engineering, one potential solution to the diffusion limitation is to create a vascular network in vitro that can(More)
Many-cache is a memory architecture that efficiently supports caching in commercially available FPGAs. It facilitates FPGA programming for high-performance computing (HPC) developers by providing them with memory performance that is greater and power consumption that is less than their current CPU platforms, but without sacrificing their familiar, C-based(More)
This poster describes CHiMPS, a toolflow that aims to provide software developers with a way to program hybrid CPU-FPGA platforms using familiar tools, languages, and techniques. CHiMPS starts with C and produces a specialized spatial dataflow architecture that supports coherent caches and the shared-memory programming model. The toolflow is designed to(More)
Tiled architectures, such as RAW, SmartMemories, TRIPS, and WaveScalar, promise to address several issues facing conventional processors, including complexity, wire-delay, and performance. The basic premise of these architectures is that larger, higher-performance implementations can be constructed by replicating the basic tile across the chip. This paper(More)
High-Performance Reconfigurable Computers (HPRCs) consist of one or more standard microprocessors tightly-coupled with one or more reconfigurable FPGAs. HPRCs have been shown to provide good speedups and good cost/performance ratios, but not necessarily ease of use, leading to a slow acceptance of this technology. HPRCs introduce new design challenges, such(More)
This paper explores hierarchical instruction scheduling for a tiled processor. Our results show that at the top level of the hierarchy, a simple profile-driven algorithm effectively minimizes operand latency. After this schedule has been partitioned into large sections, the bottom-level algorithm must more carefully analyze program structure when producing(More)
Co-cultures of endothelial cells (EC) and mesenchymal stem cells (MSC) in three-dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis in vitro. MSC provide paracrine signals that stimulate EC to form vessel-like structures, which mature as the MSC transition to the role of mural cells. In this study, vessel-like network(More)