Andrew Peng Yu

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The epilepsies are a common, clinically heterogeneous group of disorders defined by recurrent unprovoked seizures. Here we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with auditory(More)
OBJECTIVES To investigate persistence and adherence of medication treatment in chronic overactive bladder/urinary incontinence (OAB/UI) patients, and to evaluate OAB/UI-related comorbidity events associated with persistence. METHODS Pharmaceutical outcomes research with a health-care provider perspective was conducted on a California Medicaid (Medi-Cal)(More)
OBJECTIVE To conduct a critical and systematic literature review of the costs of Crohn's disease (CD) in Western industrialized countries. RESEARCH DESIGN AND METHODS Studies published in English that described the cost of CD in Western industrialized countries were identified using three major databases (Medline, EMBASE, and ISI Web of Science). Studies(More)
BACKGROUND Psoriasis is associated with health-related quality-of-life impairment and depression. OBJECTIVE We sought to determine the effect of adalimumab on depression symptoms in patients with psoriasis. METHODS Patients with moderate to severe psoriasis in a randomized, placebo-controlled, double-blind clinical trial were assessed for depression(More)
OBJECTIVE We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly. METHODS Data were extracted from the Integrated Healthcare Information Services claims database (1999-2005). Patients were included if they had gout, were aged 65 years and older and had both medical and pharmacy(More)
BACKGROUND Early onset and complications such as hospitalization and surgery contribute to the economic burden of ulcerative colitis. AIM To review systematically the literature on costs of ulcerative colitis in Western countries. METHODS Studies estimating costs of ulcerative colitis in Western countries were identified using Medline, EMBASE and ISI(More)
BACKGROUND Psoriasis is frequently associated with comorbidities. OBJECTIVE To estimate the incremental economic burden associated with comorbidities in patients with psoriasis, accounting for psoriasis severity. METHODS Patients continuously enrolled ≥6 months after a randomly selected psoriasis diagnosis date were selected from the Ingenix Impact(More)
BACKGROUND Gout is a common cause of inflammatory arthritis in the United States, and its prevalence has increased in recent decades, especially among older adults. Older adults with gout are of particular interest because they tend to experience higher rates of tophi, an advanced stage of gout, than do younger patients. OBJECTIVE For older adults with(More)
OBJECTIVES:We evaluated the effects of adalimumab maintenance therapy on health-related quality of life (HRQOL) in patients with moderate to severe Crohn's disease.METHODS:In a Phase III, randomized, double-blind clinical trial (CHARM) of moderate to severe Crohn's disease patients, HRQOL outcomes were compared between the adalimumab maintenance treatment(More)
OBJECTIVES Differential item functioning (DIF) is present when respondents of unique subgroups endorse certain items differently given the respondents have the same underlying ability. This study investigates the presence of DIF regarding chronic illnesses among items of the physical functioning (PF) and mental health (MH) domains of the SF-36 health(More)