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Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by Leishmania mexicana Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway1
Infection with lesion-derived Leishmania mexicana amastigotes inhibited LPS-induced IL-12 production by mouse bone marrow-derived macrophages. This effect was associated with expression of cysteineExpand
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Inhibitory kappa B kinases as targets for pharmacological regulation
The inhibitory kappa B kinases (IKKs) are well recognized as key regulators of the nuclear factor kappa B (NF‐κB) cascade and as such represent a point of convergence for many extracellular agentsExpand
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Differential Modulation of TLR3- and TLR4-Mediated Dendritic Cell Maturation and Function by Progesterone
The role of progesterone in modulating dendritic cell (DC) function following stimulation of different TLRs is relatively unknown. We compared the ability of progesterone to modulate murine boneExpand
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Essential Role for Verotoxin in Sustained Stress-Activated Protein Kinase and Nuclear Factor Kappa B Signaling, Stimulated by Escherichia coli O157:H7 in Vero Cells
ABSTRACT The effects of Escherichia coli O157:H7 (strains E30480 and PM601) and the associated verotoxins (VTs), VT1 and VT2, on stress-activated protein kinase and nuclear factor kappa B (NF-κB)Expand
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Enhancement of lipopolysaccharide‐stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirus‐mediated inhibition of inhibitory kappa B kinase signalling
In rat aortic smooth muscle cells (RASMCs), the putative nuclear factor kappa B (NFκB) inhibitor Pyrrolidine dithiocarbamate (PDTC) was found to inhibit lipopolysaccharide (LPS)‐stimulated NFκBExpand
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Switching leukemia cell phenotype between life and death.
Divergent life or death responses of a cell can be controlled by a single cytokine (tumor necrosis factor alpha, TNF) via the signaling pathways that respond to activation of its two receptors (TNFR1Expand
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P2X7 subunit-like immunoreactivity in the nucleus of visceral smooth muscle cells of the guinea pig
P2X receptors are adenosine 5'-triphosphate (ATP)-gated cation-selective channels. Seven cloned subunits (P2X(1-7)) are found in the plasma membrane of many cells in the brain and periphery.Expand
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Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice
Left ventricular pressure overload in response to aortic banding is an invaluable model for studying progression of cardiac hypertrophy and transition to heart failure. Traditional aortic banding hasExpand
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Selective inhibition of inhibitory kappa B kinase‐β abrogates induction of nitric oxide synthase in lipopolysaccharide‐stimulated rat aortic smooth muscle cells
In this study, we utilised a number of adenoviral constructs in order to examine the role of intermediates of the NF‐κB pathway in the regulation of inducible nitric oxide synthase (iNOS) inductionExpand
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