Andrew P. Schachat

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OBJECTIVES To describe a case-control study of risk factors for neovascular and non-neovascular age-related macular degeneration (AMD) and to present findings on associations with systemic hypertension and cardiovascular disease. METHODS Participants with and without neovascular and non-neovascular AMD were recruited from 11 ophthalmology practices in the(More)
OBJECTIVE To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study. DESIGN Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma. SETTING AND PARTICIPANTS The Barbados Eye Study included 4709 Barbados residents identified by a simple random(More)
OBJECTIVE To describe the design of the Barbados Eye Study and report on the prevalence of open angle glaucoma (OAG) in a predominantly black study population. DESIGN Population-based prevalence study. SETTING AND PARTICIPANTS Residents of Barbados, West Indies, identified from a simple random sample of Barbadian-born citizens 40 through 84 years old.(More)
The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and(More)
OBJECTIVES To report initial mortality findings from the Collaborative Ocular Melanoma Study (COMS) randomized clinical trial of iodine 125 brachytherapy vs enucleation for treatment of choroidal melanoma. METHODS Patients were evaluated for eligibility at 43 participating clinical centers in the United States and Canada. Eligible consenting patients were(More)
OBJECTIVE To evaluate the anatomical and visual outcomes of patients treated with ocriplasmin for the treatment of symptomatic vitreomacular adhesion (sVMA), including vitreomacular traction syndrome and macular holes. DESIGN Retrospective, interventional, single centre, case series. PARTICIPANTS Patients with sVMA. INTERVENTION Patients were treated(More)
OBJECTIVE To provide 9-year incidence estimates of age-related macular degeneration (AMD) in a population of African descent. DESIGN Population-based cohort study. PARTICIPANTS Two thousand seven hundred ninety-three participants (81% of eligible) after 9 years' follow-up. MAIN OUTCOME MEASURES Nine-year incidence of AMD-related features, based on(More)
PURPOSE To report 24-month vision and fluorescein angiographic outcomes from trials evaluating photodynamic therapy with verteporfin in patients with subfoveal choroidal neovascularization (CNV) caused by pathologic myopia. DESIGN AND SETTING Multicenter, double-masked, placebo-controlled, randomized clinical trial at 28 ophthalmology practices in Europe(More)
Patients with granulomatous enterocolitis, a disorder which can affect the whole alimentary tract, have a 10% chance of having an ocular complication. Experience with 47 patients seen over 20 years found different types of ocular complications. Definition of the type of complication aids in diagnosis and management of both the eye and intestine. Primary(More)
OBJECTIVE To describe the frequency and predictors of local treatment failure and enucleation after iodine 125 (I(125)) brachytherapy in patients with choroidal melanoma treated and followed up in a large randomized clinical trial. DESIGN Prospective, noncomparative, interventional case series within a randomized, multicenter clinical trial. (More)