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Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants(More)
The prokinetic effects of metoclopramide, bethanechol and L-364,718 on a semisolid meal and solid pellet gastric emptying were evaluated and compared. Each compound increased the rate of meal emptying as measured 90 min post-dose. L-364,718, a non-peptide CCK antagonist, was the most potent of these three agents with statistically significant activity(More)
BACKGROUND It has previously been reported that patients infected with Burkholderia cenocepacia (genomovar III) before lung transplantation have a poorer outcome than those with other B. cepacia complex infections. METHODS An extensive study was conducted to determine the prevalence and clonality of B. cepacia complex genomovars isolated from patients(More)
BACKGROUND India's total antibiotic use is the highest of any country. Patients often receive prescription-only drugs directly from pharmacies. Here we aimed to assess the medical advice and drug dispensing practices of pharmacies for standardised patients with presumed and confirmed tuberculosis in India. METHODS In this cross-sectional study in the(More)
Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with(More)
BACKGROUND Mismanagement of TB is a concern in the Indian private sector, and empirical management might be a key contributor. OBJECTIVE To understand factors associated with empirical diagnosis and treatment of presumed TB in India's private sector and examine their effects on TB care. DESIGN In this ethnographic study, 110 private practitioners of(More)
BACKGROUND Mumbai is a hot spot for drug-resistant TB, and private practitioners trained in AYUSH systems (Ayurveda, yoga, Unani, Siddha and homeopathy) are major healthcare providers. It is important to understand how AYUSH practitioners manage patients with TB or presumptive TB. METHODS We conducted semi-structured interviews of 175 Mumbai slum-based(More)
Utilising strategically positioned bed-mounted accelerometers, the Passive Sleep Actigraphy platform aims to deliver a non-contact method for identifying periods of wakefulness during night-time sleep. One of the key problems in developing data driven approaches for automatic sleep monitoring is managing the inherent sleep/wake class imbalance. In the(More)