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In computer systems today, speed and responsiveness is often determined by network and storage subsystem performance. Faster, more scalable networking interfaces like Fibre Channel and Gigabit Ethernet provide the scaffolding from which higher performance computer systems implementations may be constructed, but new thinking is required about how machines(More)
Alzheimer's disease (AD) is characterized neuropathologically by the deposition of different forms of amyloid beta-protein (A beta) including variable amounts of soluble species that correlate with severity of dementia. The extent of synaptic loss in the brain provides the best morphological correlate of cognitive impairment in clinical AD. Animal research(More)
In computer systems today, speed and responsiveness is often determined by network and storage subsystem performance. Faster, more scalable networking interfaces like Fibre Channel and Gigabit Ethernet provide the scaffolding from which higher performance implementations may be constructed, but new thinking is required about how machines interact with(More)
Diverse lines of evidence indicate that pre-fibrillar, diffusible assemblies of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease pathogenesis. Although the precise molecular identity of these soluble toxins remains unsettled, recent experiments suggest that sodium dodecyl sulfate (SDS)-stable Aβ dimers may be the basic building(More)
Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein (PrP(C)), but the role of this interaction in mediating the disruption of synaptic plasticity by such soluble Aβ in vitro is controversial. Here we report that intracerebroventricular injection of Aβ-containing aqueous extracts of Alzheimer's disease (AD) brain(More)
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