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The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness(More)
BACKGROUND Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS Using the Get With the Guidelines-Coronary Artery Disease database, we examined(More)
H umans require rapidly responding, tightly regulated hemostasis because of their closed high-pressure circulatory system. Minor variation in response may predispose to pathological bleeding or thrombosis. In the appropriate setting , pharmacological intervention with antiplatelet therapy stabilizes the atherothrombotic phenotype, though with con-comitant(More)
BACKGROUND AND PURPOSE Aspirin resistance may be relatively common and associated with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the lowest effective dose; however, it is not known whether the recent increased use of enteric-coated aspirin could account for aspirin resistance. This study was designed to determine whether(More)
BACKGROUND Prior studies have demonstrated an inconsistent association between patients' arrival time for acute myocardial infarction (AMI) and their subsequent medical care and outcomes. METHODS AND RESULTS Using a contemporary national clinical registry, we examined differences in medical care and in-hospital mortality among AMI patients admitted during(More)
Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial infarction (AMI) are not known. In this observational prospective study serum endoglin levels were measured by ELISA in 183 AMI patients upon(More)
AIMS Long-term benefit from coronary revascularization with drug-eluting stents (DES) relative to bare metal stents (BMS) and coronary artery bypass grafting (CABG) has not been established. One year follow-up of the ERACI III registry study showed better outcome with DES. To compare major adverse cardiac and cerebrovascular event (MACCE) rates in patients(More)
Time is a one way street— except in the Twilight Zone! —Rod Serling, host of the cult CBS television series P redictions of the demise of US preeminence in the sciences appear to have been exaggerated 1 ; at least for now, objective measurements of the investment in and the impact of biomedical research in the United States suggest that it continues to(More)
between progressive microvascular damage and intramyocardial hemorrhage in patients with reperfused anterior myocardial infarction: myocardial contrast echocardiographic study. myocardial infarc-tion after coronary reperfusion detected in vivo by magnetic resonance imaging in humans: prevalence and clinical implications. of superoxide dismutase and(More)
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