• Publications
  • Influence
IL-33 exacerbates antigen-induced arthritis by activating mast cells
  • D. Xu, H. Jiang, +8 authors F. Liew
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 5 August 2008
IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressedExpand
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Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
Sepsis is a systemic inflammatory condition following bacterial infection with a high mortality rate and limited therapeutic options. Here we show that interleukin-33 (IL-33) reduces mortality inExpand
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The cytokine interleukin-33 mediates anaphylactic shock
Anaphylactic shock is characterized by elevated immunoglobulin-E (IgE) antibodies that signal via the high affinity Fcε receptor (FcεRI) to release inflammatory mediators. Here we report that theExpand
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Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice
Rationale: Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed inExpand
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IL-33 Exacerbates Autoantibody-Induced Arthritis
Rheumatoid arthritis pathogenesis comprises dysregulation in both innate and adaptive immunity. There is therefore intense interest in the factors that integrate these immunologic pathways inExpand
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Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
IL-25 critically links rhinovirus infection and allergic asthma exacerbations. IL-25 Horns in on Asthma Attacks The common cold isn’t so common in people with asthma. Rhinoviruses—the main causes ofExpand
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Antibodies to IL-25
Anticorps dirigés contre il-25
L'invention concerne l'anticorps 2C3 et des elements de liaison a la cible a base de 2C3 qui se situe a l'interleukine-25. Ceux-ci sont utiles en therapie, par exemple, dans le traitement de l'asthme.