Andrew Morton

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To maintain neurotransmission in central neurons, several mechanisms are employed to retrieve synaptically exocytosed membrane. The two major modes of synaptic vesicle (SV) retrieval are clathrin-mediated endocytosis and activity-dependent bulk endocytosis (ADBE). ADBE is the dominant SV retrieval mode during intense stimulation, however the precise(More)
In this paper, we present a methodology, based on an Enhanced Genetic Algorithm (EGA), for assigning data objects to dual-bank memories. Our approach is global, and special effort is made to identify those objects that could potentially benefit from an assignment to a specific memory, or perhaps duplication in both memories. The enhancements to the genetic(More)
A single microRNA (miRNA) can inhibit a large number of mRNA transcripts. This widespread regulatory function has been experimentally demonstrated for a number of miRNAs. However, even when a multitude of targets is confirmed, function of a miRNA is frequently interpreted through a prism of a handful arbitrarily selected "interesting" targets. In this work(More)
— The system on chip paradigm consists of one or more instruction set processors integrated with custom hardware on a single integrated circuit. A uni-processor real-time kernel is presented that integrates hardware coprocessors by viewing them as system resources to be scheduled in conjunction with the processor. The kernel implements the earliest-deadline(More)
Although epilepsy is associated with a variety of abnormalities, exactly why some brain regions produce seizures and others do not is not known. We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clustering. A paired analysis of high and low spiking tissues recorded in vivo from 15 patients predicted 11(More)
The function of the nervous system depends on the integrity of synapses and the patterning of electrical activity in brain circuits. The rapid advances in genome sequencing reveal a large number of mutations disrupting synaptic proteins, which potentially result in diseases known as synaptopathies. However, it is also evident that every normal individual(More)
When making decisions between options, humans are expected to choose the option that returns the highest benefit. In practice, however, adding inferior alternatives to the choice set can alter these decisions. Here we investigated whether decisions over the facial features that people find healthy looking can also be affected by the context in which they(More)