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Vascular inflammation is a major contributor to the severity of acute kidney injury. In the context of vasospasm-independent reperfusion injury we studied the potential anti-inflammatory role of the Gα-related RGS protein, RGS4. Transgenic RGS4 mice were resistant to 25 min injury, although post-ischemic renal arteriolar diameter was equal to the wild type(More)
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including(More)
Activation of the NMDA receptor complex increases the intracellular free Ca2+ concentration, which in turn influences a nitric oxide synthase (NOS) activity. In this study we investigated the NOS activity after acute and chronic electroconvulsive treatment in different rat brain regions. Chronic (10 daily treatments) but not acute (single treatment)(More)
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