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Since the proposal of the sodium-gradient hypothesis, research efforts have focused on two major areas: 1) establishing the thermodynamic efficacy of the electrochemical gradient for sodium as a driving force for uphill solute accumulation, and 2) determining the mechanism of energy coupling in cotransport systems. On the whole it is now reasonably well(More)
A net absorption of oxalate and chloride was observed when isolated, short-circuited segments of rat colon were bathed by a calcium-containing buffer. Removal of calcium promoted a two-fold decrease in transmural resistance, while the net chloride flux was reduced and the net oxalate transport abolished. It was concluded that net oxalate absorption was not(More)
The effects of transport inhibitors on the movements of oxalate and chloride across the isolated short circuited rabbit colon were studied. Net oxalate absorption was shown in this species and was shown to be an energy dependent process as indicated by its sensitivity to 2-4 dinitrophenol (DNP) 10(-4)M. Mucosal addition of(More)
The effects of a dihydroxy bile salt, taurochenodeoxycholate (TCDC), on the permeability and conductance of isolated, short-circuited segments of the rabbit descending colon were examined using conventional Ussing chamber techniques. Increasing concentrations of TCDC (1-4 mM) produced dose-dependent increases in sodium backflux (JNas leads to m) and tissue(More)
Unidirectional influxes of sugars and Na from muscosal solution into the cells of rabbit ileum have been examined. The influxes of glucose, galactose, and 3-0-methyl glucose (3 MG) follow Michaelis-Menten type kinetics and are markedly dependent on the presence ofNa in the mucosal solution. For 3 MG, reduction of Na concentration causes a decrease in(More)
PEARSON, TERRY W., AND ANDREW M. GOLDNER. Calcium transport across avian uterus. I. E$Ects of electro&e substitution. Am. J. Physiol. 225(6) : 1508-l 5 12. 1973.-Unidirectional calcium fluxes from serosa to mucosa (JS,, ) and mucosa to serosa (Jmds ) were determined across the isolated quail uterus. When the tissue was bathed with normal bicarbonate buffer,(More)
PEARSON, TERRY W., AND ANDREW M. GOLDNER. Calcium transport across avian uterus. II. Effects of inhibitors and nitrogen. Am. J. Physiol. 227(2) : 465-468. 1974.-Net calcium transport in the secretory direction occurs across the in vitro quail uterus in the absence of electrochemical gradients. The metabolic inhibitor, 2,4-dinitrophenol, and anaerobiosis(More)
The effects of increasing mucosal or serosal concentrations (1-4 mM) of taurochenodeoxycholate (TCDC) on sodium chloride transport across the isolated, short-circuited rabbit colon were examined. Mucosal TCDC produced dose-related increases in tissue conductance (Gt) and the unidirectional fluxes of Na+ and Cl- and dose-related decreases in net NaCl(More)