Andrew Lucas

Michaela Lucas7
Silvana Gaudieri7
Simon Mallal6
7Michaela Lucas
7Silvana Gaudieri
6Simon Mallal
3Elizabeth McKinnon
Learn More
Many modern manufacturing systems are highly automated and are now requiring decentralised 'smart' architectures to control hardware and manage the flow of materials / knowledge, in order to provide responsiveness. This responsiveness is needed to satisfy an ever increasing consumer need for goods that satisfy their unique requirements and are delivered to(More)
We provide Ising formulations for many NP-complete and NP-hard problems, including all of Karp's 21 NP-complete problems. This collects and extends mappings to the Ising model from partitioning, covering and satisfiability. In each case, the required number of spins is at most cubic in the size of the problem. This work may be useful in designing adiabatic(More)
Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug(More)
We reported previously that a proportion of natural CD25(+) cells isolated from the PBMC of HCV patients can further upregulate CD25 expression in response to HCV peptide stimulation in vitro, and proposed that virus-specific regulatory T cells (Treg) were primed and expanded during the disease. Here we describe epigenetic analysis of the FOXP3 locus in(More)
  • Andrew Lucas, Michaela Lucas, Anette Strhyn, Niamh M. Keane, Elizabeth McKinnon, Rebecca Pavlos +10 others
  • 2015
BACKGROUND Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologically confirmed abacavir HSR can manifest clinically in less than 48 hours following first exposure suggesting(More)
  • Katja Pfafferott, Silvana Gaudieri, Axel Ulsenheimer, Ian James, Malte Heeg, David Nolan +7 others
  • 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune control. This study examined HCV evolution in 21 HCV genotype 1-infected subjects to characterise the level of(More)
We analyze the parallel performance of randomized interpolative decomposition by decomposing low rank complex-valued Gaussian random matrices up to 64 GB. We chose a Cray XMT supercomputer as it provides an almost ideal PRAM model permitting quick investigation of parallel algorithms without obfuscation from hardware idiosyncrasies. We obtain that on(More)