- Full text PDF available (3)
- This year (1)
- Last 5 years (8)
- Last 10 years (9)
Journals and Conferences
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability, and is the leading single-gene cause of autism spectrum disorders. It is due to a loss of the fragile X mental… (More)
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X… (More)
Background: Gamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABAA receptor positive allosteric modulator, is… (More)
The fragile X premutation is characterized by a repeat expansion mutation (between 55 to 200 CGG repeats) in the fragile X mental retardation 1 (FMR1) gene, which leads to RNA toxicity at the… (More)
This chapter is an up-to-date review of targeted treatment trials for patients with fragile X syndrome (FXS). Specifically, there is a focus on controlled trials directed toward cellular receptors… (More)
BackgroundGamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABAA receptor positive allosteric modulator, is… (More)
This chapter examines the relationship between neurodevelopmental disorders and aging syndromes by highlighting areas of overlap at both the molecular and clinical level. Specifically, there is a… (More)
A quick guide to common neurodevelopmental conditions and their associated late-life neuropsychiatric manifestations.
With aging, a multitude of medical conditions can occur and/or existing conditions can be exacerbated, contributing causally to or amplifying neuropsychiatric comorbidities.