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This work proposes a new meta-heuristic called Grey Wolf Optimizer (GWO) inspired by grey wolves (Canis lupus). The GWO algorithm mimics the leadership hierarchy and hunting mechanism of grey wolves in nature. Four types of grey wolves such as alpha, beta, delta, and omega are employed for simulating the leadership hierarchy. In addition, the three main(More)
PURPOSE The purpose of this investigation is to present the in vitro characterization and detailed drug-loading procedure for DC Bead, a microsphere product that can be loaded with chemotherapeutic agents for embolization. MATERIALS AND METHODS DC Bead is an embolic microsphere product that is capable of being loaded with anthracycline drugs such as(More)
PURPOSE To present the pathologic and pharmacokinetic findings from hepatic embolization in a porcine model comparing doxorubicin-eluting beads with bland embolization and to correlate these findings with in vitro release kinetics. MATERIALS AND METHODS Drug-eluting beads (DEB; 100-300 microm and 700-900 microm) loaded with 37.5 mg doxorubicin per(More)
This paper proposes a novel nature-inspired meta-heuristic optimization algorithm, called Whale Optimization Algorithm (WOA), which mimics the social behavior of humpback whales. The algorithm is inspired by the bubble-net hunting strategy. WOA is tested with 29 mathematical optimization problems and 6 structural design problems. Optimization results prove(More)
Particle Swarm Optimization (PSO) is one of the most widely used heuristic algorithms. The simplicity and inexpensive computational cost makes this algorithm very popular and powerful in solving a wide range of problems. The binary version of this algorithm has been introduced for solving binary problems. The main part of the binary version is a transfer(More)
DC Bead is a sulfonate-modified, PVA-based microspherical embolisation agent approved for the treatment of hypervascular tumours and arterio-venous malformations. The beads have previously been shown to actively sequester oppositely charged drugs, such as doxorubicin hydrochloride (dox) by an ion-exchange mechanism. In order to characterise the release(More)
DC Bead is a FDA cleared embolisation device for the treatment of hypervascular tumours and arteriovenous malformations. This product is currently evaluated in a number of centres in Europe as an embolic device for transarterial chemoembolisation (TACE). The beads consist of poly(vinyl alcohol) microspheres modified with sulfonic acid groups and are(More)
This chapter examines the performance characteristics of both asyn-chronous and synchronous parallel particle swarm optimisation algorithms in heterogeneous , fault-prone environments. The chapter starts with a simple parallelisa-tion paradigm, the Master-Slave model using Multi-Objective Particle Swarm Opti-misation (MOPSO) in a heterogeneous environment.(More)
Drug eluting beads that release irinotecan in a controlled manner may be useful for application in the chemoembolization of colorectal cancer metastases to the liver. In this study, irinotecan drug eluting beads were prepared with loadings up to 50 mg drug/mL hydrated beads. Drug loading was via an ion-exchange mechanism with sulfonate binding sites in the(More)
Disposition kinetics of [(3)H]palmitate and its low-molecular-weight metabolites in perfused rat livers were studied using the multiple-indicator dilution technique, a selective assay for [(3)H]palmitate and its low-molecular-weight metabolites, and several physiologically based pharmacokinetic models. The level of liver fatty acid binding protein (L-FABP),(More)