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PURPOSE Accommodative insufficiency (AI) and convergence insufficiency (CI) have been associated with similar symptomology and frequently present at the same time. The severity of symptomology in CI has been linked to the severity of the CI, suggesting a dose-dependent relationship. However, with increasing severity of CI also comes increased comorbidity of(More)
PURPOSE The purpose of this investigation was to measure the precorneal residence time of saline and five marketed artificial tears in dry eye subjects using fluorometry. METHODS FITC-dextran, 70 kDa molecular weight, was admixed under sterile conditions (0.1% wt/vol) into buffered saline and the marketed artificial tear formulations of varying viscosity.(More)
PURPOSE It was the purpose of this investigation to examine both retention time (RT) and retention of effect of two ophthalmic formulations in the same dry eye subjects. METHODS This was a randomized, subject-masked cross-over study. Dry eye subjects, characterized by sub-type, were recruited. For direct RT measurement, fluorescein isothiocyanate(More)
PURPOSE Dry eye disease is a common condition that affects millions of people world wide. The common findings of dry eye disease are blurred vision and tear film instability. The purpose of this study was to determine if long-term use of artificial tears altered visual disturbances and tear film instability of dry eye patients. METHODS Contrast(More)
PURPOSE The purpose of this work was to gather preliminary data in normals and dry eye subjects, using a new, non-invasive imaging platform to measure the thickness of pre-corneal tear film. METHODS Human subjects were screened for dry eye and classified as dry or normal. Tear film thickness over the inferior paracentral cornea was measured using laser(More)
PURPOSE The study purpose was to evaluate corneal barrier function and staining relative to potential bioincompatibilities. METHODS This was a randomized double-masked study (n = 25 subjects). Three lens material-care solution combinations were tested: (1) lotrafilcon B/polyhexamethylene biguanide (PHMB)-based multipurpose (MPS) solution (MPS-1); (2)(More)
PURPOSE This pilot study compared traditional methodologies; manifest refraction and keratometry, with that of newer technologies; corneal topography, and optical pachymetry, in assessing corneal and refractive stabilization after soft contact lens wear in photorefractive candidates. The timeline differences among these various technologies in determining(More)
PURPOSE The purpose of this investigation was to examine the relationship between the visual effect (VE) and residence time (RT) of artificial tears (ATs) in dry eye subjects. METHODS The VEs and RTs were measured after administration of 25 μl of an AT into the inferior fornix of 18 dry eye subjects. The VE was investigated by measuring contrast(More)