Andrew L. Chan

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Many patients with breathlessness and chronic obstructive lung disease are diagnosed with either asthma, COPD, or-frequently-mixed disease. More commonly, patients with uncharacterized breathlessness are treated with therapies that target asthma and COPD rather than one of these diseases. This common practice represents the difficulty in distinguishing(More)
The appeal of modular robotics is in their potential versatility, robustness, and low cost of manufacture. These primary advantages, however, have yet to be fully realized [1]. Due to demanding level of expertise and a prohibitively high cost of fabrication and operation, majority of current research in modular robotics is limited to specialized labs at few(More)
The diagnosis of primary central nervous system lymphoma (PCNSL) depends on histopathology of brain biopsies, because disease markers in the cerebrospinal fluid (CSF) with sufficient diagnostic accuracy are not available yet. MicroRNAs (miRNAs) are regulatory RNA molecules that are deregulated in many disease types, including cancer. Recently, miRNAs have(More)
OBJECTIVE To find biomarkers identifying patients at risk for the development of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment. METHODS Patients were recruited from 10 European and US cohorts. Of 289 patients with multiple sclerosis (MS), 224 had been treated with natalizumab (18-80 months), 21 received other(More)
BACKGROUND Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known. METHODS We screened serum IgG from persons with multiple sclerosis to identify antibodies that are capable of binding to(More)
OBJECTIVE To investigate the rate of seropositivity of anti-JC virus (JCV) antibodies in a German multiple sclerosis (MS) cohort treated with natalizumab in the postmarketing setting and to assess anti-JCV serostatus in samples obtained before diagnosis of progressive multifocal leukoencephalopathy (PML). METHODS This was a blinded, retrospective(More)
BACKGROUND Early diagnosis of pulmonary hypertension (PH) can potentially improve survival and quality of life. Detecting PH using echocardiography is often insensitive in subjects with lung fibrosis or hyperinflation. Right heart catheterization (RHC) for the diagnosis of PH adds risk and expense due to its invasive nature. Pre-defined measurements(More)
BACKGROUND The mechanisms by which mandibular advancement splints (MAS) improve obstructive sleep apnoea (OSA) are not well understood. This study aimed to evaluate the mechanism of action of MAS by assessing their effect on upper airway structure in patients with OSA. METHODS Patients were recruited from a sleep disorders clinic for treatment with a(More)
STUDY OBJECTIVES To compare the craniofacial morphological phenotype of subjects with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique. DESIGN Case-control study; subgroup matched for body mass index (BMI) and sex. SETTING Sleep investigation unit in a university teaching hospital. PATIENTS 114 subjects(More)
STUDY OBJECTIVES To develop models based on craniofacial photographic analysis for the prediction of obstructive sleep apnea (OSA). DESIGN Prospective cohort study. SETTING Sleep investigation unit in a university teaching hospital. PATIENTS One hundred eighty subjects (95.6% Caucasian) referred for the initial investigation of OSA were recruited(More)