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OBJECTIVE The goal was to examine the demographic characteristics, causative foods, clinical features, treatments, and outcomes for children presenting with acute food protein-induced enterocolitis syndrome. METHODS This was a retrospective study of children with food protein-induced enterocolitis syndrome who presented to the Children's Hospital at(More)
BACKGROUND Primary immunodeficiency disorders (PIDs) are uncommon conditions that require specialized immunologic services for diagnosis and management. It is difficult to estimate the prevalence of these disorders from routinely collected health statistics. OBJECTIVE We attempted to describe the prevalence of PID in Australia and the requirements for(More)
CONTEXT The "hygiene hypothesis" has implicated sibship as a marker of infection load during early life and suggests that exposure or reexposure to infections can influence the developing immune system. Viral infection has also been implicated in the pathogenesis of multiple sclerosis (MS). OBJECTIVES To evaluate whether exposure to infant siblings in(More)
BACKGROUND Early life exposures may be important in the development of asthma and allergic disease. OBJECTIVE To test house dust mite (HDM) avoidance and dietary fatty acid modification, implemented throughout the first 5 years of life, as interventions to prevent asthma and allergic disease. METHODS We recruited newborns with a family history of asthma(More)
OBJECTIVE To evaluate the impact of childhood atopic eczema on families and assess the personal financial cost of its management. DESIGN Cross sectional survey. SETTING Paediatric dermatology and paediatric diabetology outpatient clinics. PATIENTS Parents of 48 randomly selected children with atopic eczema and 46 with insulin dependent diabetes(More)
Low back pain is a widespread debilitating problem with a lifetime prevalence of 80%, with the underlying pain mechanism unknown in approximately 90% of cases. We used the painDETECT neuropathic pain screening questionnaire to identify likely pain mechanisms in 343 patients with low back pain with or without leg pain in southeastern England referred for(More)
There has been a marked increase in community concerns of the risk of food induced anaphylaxis in children and a consequent increase in the provision of the self or carer injectable epinephrine (EpiPen) (CSL Ltd, Parkville, Victoria, Australia)). The Australian use of EpiPens in children under 10 years has increased by 300% over 5 years with a crude rate of(More)
OBJECTIVES We investigated the role of infant bedding items, as part of a composite bedding environment, in the development of childhood wheezing. METHODS This prospective cohort investigation involved 863 children who participated in an infant survey in 1988 and an asthma study in Tasmania, Australia, in 1995. The derived 3 composite infant bedding(More)
Atopic disorders such as atopic dermatitis and asthma have been characterised by an imbalance in interferon-gamma (INF-gamma) and IL-4. Whether similar imbalances are found in atopic disorders with different clinical manifestations, such as IgE mediated immediate food hypersensitivity, is not clear. We have examined the in vitro production of INF-gamma and(More)
BACKGROUND Polyclonal cytokine responses following stimulation of T cells with mitogens or superantigens provides information on cytokine production from a wide range of T cells. Alternatively allergen-induced T cell responses can provide information on cytokine production by allergen-reactive T cells. While there is evidence of increased Th2 and reduced(More)