Andrew K Macleod

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Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of inferring(More)
Three studies examined whether the specificity with which people retrieve episodes from their past determines the specificity with which they imagine the future. In the first study, suicidal patients and nondepressed controls generated autobiographical events and possible future events in response to cues. Suicidal subjects' memory and future responses were(More)
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We(More)
To better understand the role of transcription factor NF-E2-related factor (NRF) 2 in the human and its contribution to cancer chemoprevention, we have knocked down its negative regulators, Kelch-like ECH-associated protein 1 (KEAP1) and broad-complex, tramtrack and bric à brac and cap'n'collar homology 1 (BACH1), in HaCaT keratinocytes. Whole-genome(More)
An experiment is reported that attempts to distinguish between anxious and depressive future thinking in terms of anticipation of future positive and future negative experiences. Anxious, mixed (anxious-depressed), and control participants were given an adapted verbal fluency paradigm to examine the ease with which they could think of future positive and(More)
Numerous studies have identified cognitive and affective similarities and differences between anxiety and depression but relatively little empirical research has studied these emotional disturbances from a motivational perspective. This study investigates individual response-variations on approach and avoidance goals and plans. High anxiety (n = 27), high(More)
BACKGROUND Previous research has shown that parasuicides' view of the future is characterized by an absence of anticipation of positive experiences rather than the presence of anticipation of negative experiences. The present study aimed to replicate this finding and examine whether it would also be found in parasuicides who were not depressed. METHOD(More)
BACKGROUND We carried out a large randomized trial of a brief form of cognitive therapy, manual-assisted cognitive behaviour therapy (MACT) versus treatment as usual (TAU) for deliberate self-harm. METHOD Patients presenting with recurrent deliberate self-harm in five centres were randomized to either MACT or (TAU) and followed up over 1 year. MACT(More)
OBJECTIVES The research examined: (i) whether high risk parasuicide patients showed a deficit in positive future thinking but no increase in negative future thinking; and (ii) whether such a deficit could be remedied by a brief, manual-assisted psychological intervention (manual assisted cognitive-behaviour therapy; MACT). DESIGN A cross-sectional, mixed(More)
Positron emission tomographic imaging of regional cerebral blood flow changes during panic and anticipatory anxiety has permitted the investigation of the functional brain anatomy of anxiety (1, 2). The largest blood flow change found in these studies occurred bilaterally in the vicinity of the pole of the temporal lobe. This was thought to represent(More)