Andrew K. C. Lam

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BACKGROUND The duration of action of the immediate-release formulation of methylphenidate hydrochloride is short (3 to 4 hours), and 3 times daily dosing is thought to maximize effectiveness across a 12-hour day. The initial sustained-release formulations of methylphenidate had reduced efficacy compared with immediate-release methylphenidate and were not(More)
PURPOSE To obtain the retinal nerve fiber layer (RNFL) thickness normative values of Hong Kong children by using optical coherence tomography (OCT) and to investigate the effect of age and axial length (AL) on RNFL thickness. PATIENTS AND METHODS One hundred and four normal children aged between 6 and 17 years were recruited for this study. The RNFL(More)
The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic approach to targeting the Wnt pathway with a monoclonal antibody, OMP-18R5. This antibody, initially identified by binding to Frizzled 7, interacts with five Fzd receptors through(More)
PURPOSE To compare intraocular pressure (IOP) obtained from the ocular response analyzer (ORA) and Goldmann applanation tonometer (GAT) on a group of normal Chinese. METHODS One hundred twenty-five normal subjects were recruited, with one eye randomly selected for this study. Each eye was measured first with the noncontact tonometer ORA, followed by the(More)
PURPOSE To determine the intraexaminer repeatability and intersession reproducibility of corneal deformation measurement using Scheimpflug noncontact tonometry (Corvis ST) on normal subjects. METHODS Thirty-seven adults aged 20 to 48 years were invited to have their corneal deformation and curvature measurements taken using Corvis ST and Pentacam,(More)
The posterior corneal p-value and apical radius of 60 Hong Kong Chinese were assessed. The values were derived based on the information of the anterior corneal topography and the corneal thickness in different regions. The mean posterior corneal apical radius along the horizontal meridian was 6.51 mm (SD +/- 0.40 mm) and the p-value was 0.34 (SD +/- 0.38).(More)
PURPOSE Pulsatile ocular blood flow (POBF) assessment measures the choroidal circulation and provides diagnostic value to certain ocular diseases such as glaucoma. This technique assumes a constant ocular rigidity and is influenced by axial length, diurnal variation, and age. This study investigated the effect of age on POBF, with consideration of the above(More)
PURPOSE To observe the roles of cornea and axial length (AL) in corneal hysteresis (CH) among emmetropes and high myopes. MATERIALS AND METHODS The CH, corneal resistance factor (CRF) and corneal-compensated intraocular pressure (IOPcc) of 40 young emmetropes (spherical equivalent +/-0.50 D) and 40 age-matched high myopes (-6D or more) were measured by(More)
Inhibitors of angiogenic factors are known to be upregulated, and their levels increase in the maternal circulation before the onset of preeclampsia. We reproduced a previously characterized model of preeclampsia by adenoviral overexpression of the soluble vascular endothelial growth factor (VEGF) receptor sFlt-1 (also referred to as sVEGFR-1) in pregnant(More)
Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-beta activity in gliomas is to disrupt the signaling cascade at the level of the TGF-beta receptor I (TGF-betaRI) kinase, thus abrogating TGF-beta-mediated invasiveness(More)