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Small heat shock proteins (sHSPs) are essential 'holdase' chaperones that form large assemblies and respond dynamically to pH and temperature stresses to protect client proteins from aggregation. While the alpha-crystallin domain (ACD) dimer of sHSPs is the universal building block, how the ACD transmits structural changes in response to stress to promote(More)
Evaluating academic and student affairs partnerships: the impact of living-learning communities on the development of critical thinking skills in college freshmen. 1 ABSTRACT This dissertation was the first study to estimate the direct and indirect effects of living-learning community (LLC) participation on a standardized measure of critical thinking using(More)
Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) ion channels play crucial physiological roles in phototransduction, olfaction, and cardiac pace making. These channels are characterized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD) that connects to the channel pore via a(More)
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