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This paper presents a framework for process mining in critical care. The framework uses the CRISP-DM model, extended to incorporate temporal and multidimensional aspects (CRISP-TDM n), combined with the Patient Journey Modeling Architecture (PaJMa), to provide a structured approach to knowledge discovery of new condition onset pathophysiologies in(More)
BACKGROUND The realm of pathological entities can be subdivided into pathological dispositions, pathological processes, and pathological structures. The latter are the bearer of dispositions, which can then be realized by their manifestations - pathologic processes. Despite its ontological soundness, implementing this model via purpose-oriented domain(More)
This paper describes the deployment of a platform to enable processing of currently uncharted high frequency, high fidelity, synchronous data from medical devices. Such a platform would support the next generation of informatics solutions for neonatal intensive care. We present Artemis, a platform for real-time enactment of clinical knowledge as it relates(More)
We present a framework to model and translate clinical rules to support complex real-time analysis of both synchronous physiological data and asynchronous clinical data. The framework is demonstrated through a case study in a neonatal intensive care context showing how a clinical rule for detecting an apnoeic event is modeled across multiple physiological(More)
In land plants, the NAD(P)H dehydrogenase (NDH) complex reduces plastoquinones and drives cyclic electron flow (CEF) around PSI. It also produces extra ATP for photosynthesis and improves plant fitness under conditions of abiotic environmental stress. To elucidate the role of CEF in salt tolerance of the photosynthetic apparatus, Na(+) concentration,(More)
BACKGROUND Patients with multiple conditions have complex needs and are increasing in number as populations age. This multimorbidity is one of the greatest challenges facing health care. Having more than 1 condition generates (1) interactions between pathologies, (2) duplication of tests, (3) difficulties in adhering to often conflicting clinical practice(More)
Amplitude-integrated electroencephalography (aEEG) is a technique that compresses the time scale of conventional electroencephalography (EEG) and is displayed on Cerebral Function Monitors (CFM). This is advantageous for interpreting global cerebral activity in neonates, including sleep patterns. Sleep-wake cycling in infants is often used as an indicator(More)
Maintaining blood oxygen saturation within the intended target range for preterm infants receiving neonatal intensive care is challenging. Supplemental oxygen is believed to lead to increased risk of retinopathy of prematurity and hence managing the level of oxygen within this population is important within their care. Current quality improvement activities(More)