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Human RNA Polymerase III transcriptomes and relationships to Pol II promoters, enhancer-binding factors and chromatin domains
RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs) important for translational capacity and other functions. We localized Pol III, alternative TFIIIB complexesExpand
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PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression
Maf1 is the ‘master’ repressor of RNA polymerase III (Pol III) transcription in yeast, and is conserved in eukaryotes. Maf1 is a phospho‐integrator, with unfavourable growth conditions leading toExpand
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SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation
Short interspersed nuclear elements (SINEs), such as Alu, spread by retrotransposition, which requires their transcripts to be copied into DNA and then inserted into new chromosomal sites. This canExpand
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Alu expression in human cell lines and their retrotranspositional potential
BackgroundThe vast majority of the 1.1 million Alu elements are retrotranspositionally inactive, where only a few loci referred to as ‘source elements’ can generate new Alu insertions. The first stepExpand
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Third Report on Chicken Genes and Chromosomes 2015
Opening insights into new technologies in avian genomics The chicken has long been a model organism for genetic and developmental studies. It is now beginning to take its place as a model genome,Expand
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Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease.
CARD11 encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream signaling to NF-κB, JNK, and mTORC1. Germline CARD11 mutations cause several distinct primaryExpand
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