Andrew J Wyss

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The role of brain P450 in the physiology, pharmacology and toxicology of the brain is the subject of this study. Cytochrome P450 was isolated from the brains of rats and quantitated spectrally. The contribution of the known hepatic forms of the enzyme to the forms constitutive in the brain as well as those which are induced by hormones are xenobiotics were(More)
The plasma levels of ropivacaine HCl with 5 mcg/mL epinephrine were measured in 10 patients following scalp blockade for awake craniotomy. A mean dose of 260 mg (3.6 mg/kg) resulted in peak plasma concentrations of 1.5 +/- 0.6 mcg/mL, with a median time to peak plasma concentration of 15 minutes. The pattern of rise of plasma level was similar in all(More)
Cytochrome P450 was partially purified from rat breast tissue from 1-, 2-, 3-, 6-, 9-, and 15-week-old pregnant, lactating, or 3-week postlactation rats. The detergent-solubilized P450 was spectrally quantified, and the P450 isozyme pattern in the different samples was characterized by Western blot analysis with antibodies against cytochromes P450 1A1, 1A2,(More)
Twenty-four hr after a single dose of the neuroleptic drug clozapine, cytochrome P4502D4 (P4502D4) immunoreactivity, which was barely detectable in the brains of untreated rats, was clearly evident in neurons of the substantia nigra pars compacta, ventral tegmental area, granular neurons of the olfactory bulb, and Purkinje and granular neurons of the(More)
The possible relationship between cytochrome P450 (P450) in brain and degenerative diseases of the central nervous system prompted an investigation into the members of the 2D subfamily in rat brain. The mRNA for P450 2D4 was much more abundant than those for 2D1 and 2D5, which are major hepatic forms. 2D2 and 2D3 mRNAs, which are also abundant forms in(More)
STUDY DESIGN This was a prospective cohort study. OBJECTIVES The objective was to describe the incidence, prevalence, characteristics of pressure ulcers (PUs) and the association with specific patient characteristics in a consecutive sample of in-patients with a spinal cord injury (SCI). SETTING An acute care and rehabilitation clinic specialized in(More)
STUDY DESIGN Cross-sectional validation study. OBJECTIVES To develop and validate a self-report version of the Spinal Cord Independence Measure (SCIM III). SETTING Two SCI rehabilitation facilities in Switzerland. METHODS SCIM III comprises 19 questions on daily tasks with a total score between 0 and 100 and subscales for 'self-care', 'respiration &(More)
In 67 diaphyseal femoral fractures in adults treated by plating, the average follow-up time was 5 years. Sixty per cent of the patients suffered multiple injuries; 69% of the fractures were comminuted. The goal of treatment was rigid internal fixation. However, bridging of the comminuted area with a plate was sometimes necessary to maintain length as well(More)