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Current therapeutic strategies are proving inadequate to deal with growing obesity rates because of the inherent resistance of the human body to weight loss. The activation of human brown adipose tissue (BAT) represents an opportunity to increase energy expenditure and weight loss alongside improved lipid and glucose homeostasis. Research into the(More)
Invasive plant populations typically consist of a large (main) focus and several smaller outlier populations. Management of the spread of invasives requires repeated control measures, constrained by limited funding and effort. Posing this as a control problem, we investigate whether it is best to apply control to the main focus, the outlier populations, or(More)
Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT is therefore of great importance for developing strategies to treat metabolic diseases. Here we show that the soluble form of the(More)
Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. The effects of nicotine on energy homeostasis have been mostly pinpointed in the central(More)
Biopsies following positron emission tomography coupled to computer tomography (PET-CT) imaging have confirmed the presence of thermogenically active brown adipose tissue (BAT) in adult humans, leading to suggestions that it could be stimulated to treat obesity and its associated morbidities. The mechanisms regulating thermogenesis in BAT are better(More)
Brown adipose tissue (BAT) has evolved to generate heat to maintain core body temperature, but it is also of great importance for the regulation of energy balance. In addition to BAT, mammals can induce the formation of "brown adipocyte-like" or "beige" fat cells in white adipose tissue and understanding their regulation could have implications for the(More)
Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies. However, previous attempts to manipulate BAT's sympathetic activation have lacked specificity. In this issue of the JCI, Bordicchia et al.(More)
Water distribution infrastructure worldwide is aging, resulting in increasing failures and underscoring the need for real-time monitoring to avoid interruption of an essential service. In this research an end-to-end integrated hardware and software system was developed for monitoring, analyzing, and modeling large urban water distribution systems in real(More)
Obesity rates are increasing alongside those of its co-morbidities, placing a huge strain on health systems across the globe. Evidence points to inappropriate levels of ectopic lipid accumulation outside of adipose tissue being a major factor in the progression of many of these diseases. Brown adipose tissue (BAT) has a huge capacity to remove lipids from(More)