Andrew J Sommerfield

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OBJECTIVE To examine the effects of acute hyperglycemia on cognitive function and mood in people with type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty subjects with type 2 diabetes, median age 61.5 years (range 53.1-72.0), known duration of diabetes 5.9 years (range 2.8-11.2), BMI 29.8 kg/m2 (range 22.0-34.6), and HbA1c 7.5% (range 6.7-8.4) were(More)
OBJECTIVE To examine the effects of acute insulin-induced hypoglycemia on short-term, delayed, and working memory in individuals with type 1 diabetes. RESEARCH DESIGN AND METHODS A hyperinsulinemic glucose clamp was used to maintain arterialized blood glucose level at either 4.5 mmol/l (euglycemia) or 2.5 mmol/l (hypoglycemia) on two separate occasions in(More)
The effects of acute insulin-induced hypoglycemia on short-term, delayed, and working memory were examined in healthy adults. A hyperinsulinemic glucose clamp was used to maintain arterialized blood glucose at either 4.5 (euglycemia) or 2.5 (hypoglycemia) mmol/L on 2 separate occasions in 16 healthy volunteers. Tests of immediate and delayed verbal memory,(More)
AIMS To examine the effects of acute insulin-induced hypoglycaemia on different aspects of attention and on general non-verbal reasoning in people with Type 1 diabetes. METHODS A hyperinsulinaemic glucose clamp was used to maintain euglycaemia (4.5 mmol/l) or induce hypoglycaemia (2.6 mmol/l) on separate occasions in 16 adults with Type 1 diabetes each of(More)
A cute hypoglycemia causes a progressive , reversible deterioration in cognitive function that becomes detectable at blood glucose concentrations below ϳ3.0 –3.4 mmol/l (1). In an earlier study in nondiabetic subjects, we reported that several facets of attention deteriorated significantly at an arterialized blood glucose level of 2.6 mmol/l (2). However,(More)
INTRODUCTION Some aspects of memory performance are impaired during acute hypoglycaemia. The hippocampus is critical to formation of long-term memory, and may be particularly sensitive to hypoglycaemia. This study examined whether moderate hypoglycaemia occurring after learning would disrupt the consolidation process, and used functional magnetic resonance(More)
AIMS To examine the effect of acute hypoglycemia on motivation and cognitive interference in adult humans with type 1 diabetes. METHODS A hyperinsulinemic glucose clamp was used to either maintain euglycemia (arterialized blood glucose 4.5 mmol/L) or induce hypoglycemia (2.6 mmol/L) in 16 adults with type 1 diabetes, each of whom were studied on 2(More)
1 I nsulin-induced hypoglycemia provokes counterregulatory hormonal responses , the magnitude of which is lower in women with and without type 1 diabetes than in their male counterparts (1–5), although the glycemic thresholds at which these responses are triggered are similar in both sexes (6,7). In nondiabetic adults and people with type 1 diabetes,(More)
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