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—This paper describes an area and power-efficient VLSI approach for implementing the discrete wavelet transform on streaming multielectrode neurophysiological data in real time. The VLSI implementation is based on the lifting scheme for wavelet computation using the symmlet4 basis with quantized coefficients and integer fixed-point data precision to(More)
Modern microelectrode arrays acquire neural signals from hundreds of neurons in parallel that are subsequently processed for spike sorting. It is important to identify, extract, and transmit appropriate features that allow accurate spike sorting while using minimum computational resources. This paper describes a new set of spike sorting features, explicitly(More)
An integrated CMOS amperometric instrument with on-chip electrodes and packaging for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in 0.5 μm CMOS, the 3 × mm(2) chip dissipates 22.5 mW for a(More)
Soils in permafrost regions contain twice as much carbon as the atmosphere, and permafrost has an important influence on the natural and built environment at high northern latitudes. The response of permafrost to warming climate is uncertain and occurs on time scales longer than those assessed by direct observation. We dated periods of speleothem growth in(More)
Protein-based bioelectrochemical interfaces offer great potential for rapid detection, continuous use, and miniaturized sensor arrays. This paper introduces a microsystem platform that enables multiple bioelectrochemical interfaces to be interrogated simultaneously by an onchip amperometric readout system. A post-complementary metal-oxide semiconductor(More)
Spike detection from high data rate neural recordings is desired to ease the bandwidth bottleneck of bio-telemetry. An appropriate spike detection method should be able to detect spikes under low signal-to-noise ratio (SNR) while meeting the power and area constraints of implantation. This paper introduces a spike detection system utilizing lifting-based(More)