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Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of-function effects. In the hereditary degenerative disease myotonic dystrophy type 1 (DM1), transcripts from the mutant allele contain an expanded CUG repeat and are retained in the nucleus. The mutant RNA exerts a toxic gain-of-function(More)
Matrix metalloproteases (MMPs) play important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis, and cancer. MMPs have been viewed as matrix-degrading enzymes, but recent studies have shown that they possess direct signaling capabilities. Platelets harbor several MMPs that modulate(More)
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles. Enzyme replacement therapy using recombinant human GAA (rhGAA) has proven beneficial in addressing several aspects of the disease such as(More)
This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents(More)
Working at a computer is part of a large number of jobs and has been associated with upper extremity musculoskeletal disorders and back pain. The study evaluated the effects of a board attachment on upper extremity and back. The findings are mixed in that the board may have a positive effect in preventing back pain, but may be detrimental to upper(More)
Laterality difference in strength characterize some sports and occupations. The purposes of this study were to compare oarside and nonoarside knee extensor strength of intercollegiate rowers and to determine the relationship between joint-specific strength measures and rowing ergometer performance. Fifteen light-weight sweep oarsmen performed(More)
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