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Whole slide imaging (WSI), or "virtual" microscopy, involves the scanning (digitization) of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI(More)
This paper outlines the findings of ongoing research on the application of multi-agent simulations (MAS) to modelling complex locally interacting dynamic systems, in particular the petrol price market. The development of an agent based model for petrol prices is presented. Failings within this model are discussed and an alternative strategy for controlling(More)
Over 90% of cancer-related deaths in clear cell renal cell carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy of the current clinical-based models of prognosis assessment. The objective of this study is to evaluate the potential significance of lactate(More)
BACKGROUND Prostate cancer (CaP) is a disease with multifactorial etiology that includes both genetic and environmental components. The knowledge of the genetic basis of CaP has increased over the past years, mainly in the pathways that underlie tumourigenesis, progression and drug resistance. The vast majority of cases of CaP are adenocarcinomas that(More)
interface called CASWEB. b. All maps are based on data provided by the United Kingdom Boundary Outline and Reference Database for Education and Research Study (UKBORDERS) via Edinburgh University Data Library (EDINA) with the support of the Economic and Social Research Council (ESRC) and the Joint Information Systems Committee (JISC) and boundary material(More)
Augmented Reality (AR) is a technology that allows information stored digitally to be overlaid graphically on views of the real world. A vast amount of such information currently resides in office-based computer systems but is not readily accessible to engineers and managers in the field. This paper addresses research being undertaken for AR systems that(More)
Prostate cancer is a leading cause of cancer death for men in the United States. Fortunately, the survival rate for early diagnosed patients is relatively high. Therefore, in vivo imaging plays an important role for the detection and treatment of the disease. Accurate prostate cancer localization with noninvasive imaging can be used to guide biopsy,(More)
The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports the notion that deregulated accumulation of HIF upon the loss of VHL is crucial(More)
The recent description of novel recurrent gene fusions in approximately 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse(More)