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Whole slide imaging (WSI), or "virtual" microscopy, involves the scanning (digitization) of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI(More)
Prostate cancer is a leading cause of cancer death for men in the United States. Fortunately, the survival rate for early diagnosed patients is relatively high. Therefore, in vivo imaging plays an important role for the detection and treatment of the disease. Accurate prostate cancer localization with noninvasive imaging can be used to guide biopsy,(More)
The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports the notion that deregulated accumulation of HIF upon the loss of VHL is crucial(More)
The recent description of novel recurrent gene fusions in approximately 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse(More)
Prostate cancer is one of the leading causes of cancer death for men. However, early detection before cancer spreads beyond the prostate can reduce the mortality. Therefore, invivo imaging techniques play an important role to localize the prostate cancer for treatment. Although Magnetic Resonance Imaging (MRI) has been proposed to localize prostate cancer,(More)
This paper outlines the findings of ongoing research on the application of multi-agent simulations (MAS) to modelling complex locally interacting dynamic systems, in particular the petrol price market. The development of an agent based model for petrol prices is presented. Failings within this model are discussed and an alternative strategy for controlling(More)
Apoptosis is a fundamental host defence mechanism against invading microbes. Inactivation of NF-kappaB attenuates encephalomyocarditis virus (EMCV) virulence by triggering rapid apoptosis of infected cells, thereby pre-emptively limiting viral replication. Recent evidence has shown that hypoxia-inducible factor (HIF) increases NF-kappaB-mediated(More)
  • Roxana I Sufan, Eduardo H Moriyama, Adrian Mariampillai, Olga Roche, Andrew J Evans, Nehad M Alajez +5 others
  • 2009
Tumour hypoxia promotes the accumulation of the otherwise oxygen-labile hypoxia-inducible factor (HIF)-a subunit whose expression is associated with cancer progression, poor prognosis and resistance to conventional radiation and chemotherapy. The oxygen-dependent degradation of HIF-a is carried out by the von Hippel–Lindau (VHL) protein-containing E3 that(More)