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Whole slide imaging (WSI), or "virtual" microscopy, involves the scanning (digitization) of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI(More)
This paper outlines the findings of ongoing research on the application of multi-agent simulations (MAS) to modelling complex locally interacting dynamic systems, in particular the petrol price market. The development of an agent based model for petrol prices is presented. Failings within this model are discussed and an alternative strategy for controlling(More)
For sea turtles nesting on beaches surrounded by coral reefs, the most important element of hatchling recruitment is escaping predation by fish as they swim across the fringing reef, and as a consequence hatchlings that minimize their exposure to fish predation by minimizing the time spent crossing the fringing reef have a greater chance of surviving the(More)
interface called CASWEB. b. All maps are based on data provided by the United Kingdom Boundary Outline and Reference Database for Education and Research Study (UKBORDERS) via Edinburgh University Data Library (EDINA) with the support of the Economic and Social Research Council (ESRC) and the Joint Information Systems Committee (JISC) and boundary material(More)
Digital imaging in pathology has undergone an exponential period of growth and expansion catalyzed by changes in imaging hardware and gains in computational processing. Today, digitization of entire glass slides at near the optical resolution limits of light can occur in 60 s. Whole slides can be imaged in fluorescence or by use of multispectral imaging(More)
Prostate cancer is a leading cause of cancer death for men in the United States. Fortunately, the survival rate for early diagnosed patients is relatively high. Therefore, in vivo imaging plays an important role for the detection and treatment of the disease. Accurate prostate cancer localization with noninvasive imaging can be used to guide biopsy,(More)
The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports the notion that deregulated accumulation of HIF upon the loss of VHL is crucial(More)
BACKGROUND Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. Metastatic RCC is difficult to treat. The 5-year survival rate for metastatic RCC is ≤10%. Recently, microRNAs (miRNAs) have been shown to have a role in cancer metastasis and potential as prognostic biomarkers in cancer. METHOD We performed a miRNA microarray to(More)
The recent description of novel recurrent gene fusions in approximately 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse(More)
Prostate cancer is one of the leading causes of cancer death for men. However, early detection before cancer spreads beyond the prostate can reduce the mortality. Therefore, invivo imaging techniques play an important role to localize the prostate cancer for treatment. Although Magnetic Resonance Imaging (MRI) has been proposed to localize prostate cancer,(More)