Learn More
Traditional methods of public participation in environmental decisionmaking focus on two aspects of the planning system, the development control process and the development plan process. Development control is a process that regulates the development and use of land, and the development plan provides a strategic land-use framework for a city or region. The(More)
This paper outlines the findings of ongoing research on the application of multi-agent simulations (MAS) to modelling complex locally interacting dynamic systems, in particular the petrol price market. The development of an agent based model for petrol prices is presented. Failings within this model are discussed and an alternative strategy for controlling(More)
Whole slide imaging (WSI), or "virtual" microscopy, involves the scanning (digitization) of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI(More)
Over 90% of cancer-related deaths in clear cell renal cell carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy of the current clinical-based models of prognosis assessment. The objective of this study is to evaluate the potential significance of lactate(More)
BACKGROUND Preclinical data suggest that TMPRSS2-ERG gene fusions, present in about 50% of prostate cancers, may be a surrogate for DNA repair status and therefore a biomarker for DNA-damaging agents. To test this hypothesis, we examined whether TMPRSS2-ERG status was associated with biochemical failure after clinical induction of DNA damage following(More)
BACKGROUND Prostate cancer (CaP) is a disease with multifactorial etiology that includes both genetic and environmental components. The knowledge of the genetic basis of CaP has increased over the past years, mainly in the pathways that underlie tumourigenesis, progression and drug resistance. The vast majority of cases of CaP are adenocarcinomas that(More)
interface called CASWEB. b. All maps are based on data provided by the United Kingdom Boundary Outline and Reference Database for Education and Research Study (UKBORDERS) via Edinburgh University Data Library (EDINA) with the support of the Economic and Social Research Council (ESRC) and the Joint Information Systems Committee (JISC) and boundary material(More)
The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports the notion that deregulated accumulation of HIF upon the loss of VHL is crucial(More)
Prostate cancer is a leading cause of cancer death for men in the United States. Fortunately, the survival rate for early diagnosed patients is relatively high. Therefore, <i>in vivo</i> imaging plays an important role for the detection and treatment of the disease. Accurate prostate cancer localization with noninvasive imaging can be used to guide biopsy,(More)
The recent description of novel recurrent gene fusions in approximately 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse(More)