Andrew Isaac

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BACKGROUND Early worsening of anxiety, agitation and irritability are thought to be common among people commencing antidepressants, especially for anxiety disorders. This phenomenon, which may be termed jitteriness/anxiety syndrome, is cited as an explanation for early treatment failure and caution in using selective serotonin reuptake inhibitors (SSRIs).(More)
Gas chromatography–mass spectrometry (GC-MS) is a technique frequently used in targeted and non-targeted measurements of metabolites. Most existing software tools for processing of raw instrument GC-MS data tightly integrate data processing methods with graphical user interface facilitating interactive data processing. While interactive processing remains(More)
Learning to fly an aircraft is a complex task that requires the development of control skills and goal achievement strategies. This paper presents a behavioural cloning system that learns to successfully fly manoeuvres, in turbulence, of a realistic aircraft simulation. A hierarchical decomposition of the problem is employed where goal settings and the(More)
The mechanistic links between climate and the environmental sensitivities of organisms occur through the microclimatic conditions that organisms experience. Here we present a dataset of gridded hourly estimates of typical microclimatic conditions (air temperature, wind speed, relative humidity, solar radiation, sky radiation and substrate temperatures from(More)
The metabolic fate of a compound can often determine the success of a new drug lead. Thus, significant effort is directed toward identifying the metabolites formed from a given molecule. Here, an automated and nontargeted procedure is introduced for detecting drug metabolites without authentic metabolite standards via the use of stable isotope labeling,(More)
in anxiety, agitation and irritability. Medical literature and guidelines cite this phenomenon, advising caution when prescribing selective serotonin reuptake inhibitors (SSRIs), especially for anxiety disorders. This phenomena is also used to support theoretical hypotheses of antidepressant action. However, we believe it remains inconsistently and poorly(More)
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