Andrew Irwin

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BACKGROUND Vitamin D supplementation for the prevention of rickets is one of the oldest and most effective prophylactic measures in medicine, having virtually eradicated rickets in North America. Given the potentially toxic effects of vitamin D, the recommendations for the optimal dose are still debated, in part owing to the increased incidence of(More)
UNLABELLED Aim. The aim of this study was to investigate the influence of age, gender, obesity and scaling on glomerular filtration rate (GFR) and extracellular fluid volume (ECV) in healthy subjects. METHODS This is a retrospective multi-centre study of 1878 healthy prospective kidney transplant donors (819 men) from 15 centres. Age and body mass index(More)
The objective of the study was to undertake a clinical audit of departmental performance in the measurement of glomerular filtration rate (GFR) using the coefficient of variation (CV) of extracellular fluid volume (ECFV) as the benchmark. ECFV is held within narrow limits in healthy subjects, narrower than GFR, and should therefore have a low CV. Fifteen(More)
Scapho-trapezoid osteoarthritis may accompany osteoarthritis of the CM joint of the thumb. If the scapho-trapezoid joint is not excised when performing an excision of the trapezium with ligament reconstruction and interposition of the tendon of the FCR, the procedure may be unsuccessful. We describe three patients with four thumbs in which scapho-trapezoid(More)
The variability of a method for clinical and functional assessment of the long-term results of surgical correction of idiopathic congenital talipes equino varus was studied in ten boys and four girls (average age: 19.1 (SD 2.3 years); 22 affected feet) with radiographical evidence of fusion of the foot and ankle ossification centres. Patients were measured(More)
Relieve of pain and increased stability at the base of 1st metacarpal. Painful degenerative and inflammatory arthritis in trapeziometacarpal joint (TMCJ). Patients not willing to undergo lengthy intensive postoperative rehabilitation. Rheumatoid arthritis (relative). Supine. Hand table. General or regional anaesthesia. Modification of the Burton-Pelligrini(More)
BACKGROUND The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis(More)
The association between Achilles tendon rupture and sciatica was investigated by questionnaire in 138 patients who underwent repair of an Achilles tendon rupture, and in a group of individuals nominated by the patients, matched for age, sex, and occupation. A total of 102 patients (74%) and 128 peer nominated controls (71%) replied to the questionnaire. Of(More)
OBJECTIVE The objective was to assess body surface area (BSA) for scaling extracellular fluid volume (ECV) in comparison with estimated lean body mass (LBM) and total body water (TBW) across a range of body mass indices (BMI). METHODS This was a multi-centre study from 15 centres that submitted raw data from routine measurement of GFR in potential kidney(More)
BACKGROUND Many shoulder surgeons use intra-articular corticosteroid injections (IACI) in shoulder osteoarthritis, with the caveat that it precludes arthroplasty for at least 6 months to 12 months because of the theoretical risk of infection. To our knowledge, there is nothing available in the literature to support this notion. METHODS We undertook a(More)