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  • G. Tognoni, Charles Medawar, +66 authors A. J. Bayer
  • 2005
The use of n i f e d i p i n e (Nit) in the treatment of hypertension i s l imi ted by rapid b i o i n a c t i v a t i o n . Therefore a sustained re lease t a b l e t (NifSR) has been developed. Our study was designed to compare the pharmacokineties of NifSR (20 mg) with those of a capsule (NifCap; 2xlO mg) and an i.v. injection (Nifiv; O.O15 mg/kg) in(More)
We systematically analysed two complementary samples of emails relating to patients' problems with the popular SSRI antidepressant, paroxetine. These mainly concerned serious mood disorders and drug withdrawal symptoms. 1,374 emails were immediate responses to a major BBC-TV documentary programme. These were contrasted with 862 messages on similar themes(More)
Recent regulatory warnings about adverse behavioural effects of antidepressants in susceptible individuals have raised the profi le of these issues with clinicians, patients, and the public. We review available clinical trial data on paroxetine and sertraline and pharmacovigilance studies of paroxetine and fl uoxetine, and outline a series of medico-legal(More)
OBJECTIVE To explore why, at the turn of the 21st century, many people with epilepsy still want more information. METHODS Qualitative study with a maximum variation sample in the UK. We interviewed 38 men and women, 35 with epilepsy and three carers of people with epilepsy, recruited through GPs, neurologists, support groups and charities. RESULTS(More)
BACKGROUND As every healthcare intervention carries some risk of harm, clinical decision making needs to be supported by a systematic assessment of the balance of benefit to harm. A systematic review that considers only the favourable outcomes of an intervention, without also assessing the adverse effects, can mislead by introducing a bias favouring the(More)
BACKGROUND Postpartum depression is a common complication of childbirth, affecting approximately 13% of women. A hormonal aetiology has long been hypothesised due to the sudden and substantial fluctuations in concentrations of steroid hormones associated with pregnancy and the immediate postpartum period. There is also convincing evidence that oestrogens,(More)
BACKGROUND Jet-lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world. OBJECTIVES To(More)
BACKGROUND Patient organisations may be exposed to conflicts of interest and undue influence through pharmaceutical industry (Pharma) donations. We examined advertising and disclosure of financial support by pharmaceutical companies on the websites of major patient organisations. METHOD Sixty-nine national and international patient organisations covering(More)
The information content of 6,710 advertisements for medicines in medical journals was surveyed to provide a baseline for monitoring the effect of WHO's Ethical Criteria for Medicinal Drug Promotion. The advertisements (ads) appeared during 12 months (1987-1988) in 23 leading national medical journals in 18 countries. Local participants, mostly doctors or(More)