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In this paper, we give a status report of a real-world application scenario that uses two distinct types of workflow within the Triana problem solving environment: serial scientific workflow for the data processing of gravitational waves signals; and the distributed workflows that dynamically map to the virtual Grid overlay of Triana services. We briefly(More)
The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath/) currently contains 43,229 domains classified into 1467 superfamilies and 5107 sequence families. Each structural family is expanded with sequence relatives from GenBank and completed genomes, using a variety of efficient sequence search protocols and reliable thresholds.(More)
In this paper, we describe the graphical abstractions for Grids and services that have been implemented within the Triana problem solving environment. We provide an overview of the ways in which Triana interacts with services (e.g., Web and P2P services) and then how we interact with core Grid components, such as resource managers and data management(More)
We present CATHEDRAL, an iterative protocol for determining the location of previously observed protein folds in novel multidomain protein structures. CATHEDRAL builds on the features of a fast secondary-structure-based method (using graph theory) to locate known folds within a multidomain context and a residue-based, double-dynamic programming algorithm,(More)
There is a pressing need for the archiving and curation of raw X-ray diffraction data. This information is critical for validation, methods development and improvement of archived structures. However, the relatively large size of these data sets has presented challenges for storage in a single worldwide repository such as the Protein Data Bank archive. This(More)
OBJECTIVE Consumption of high fructose corn syrup (HFCS)-sweetened beverages increases serum urate and risk of incident gout. Genetic variants in SLC2A9, that exchanges uric acid for glucose and fructose, associate with gout. We tested association between sugar (sucrose)-sweetened beverage (SSB) consumption and prevalent gout. We also tested the hypothesis(More)