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  • Andrew Harkin, Karen H Bruce, Buz Craft, Ian A. Paul
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1999 (First Publication: 1 May 1999)
  • Previous studies have demonstrated that antagonists at the NMDA receptor are as efficacious as tricyclic antidepressants in pre-clinical antidepressant screening procedures and in blocking orContinue Reading
  • Valentina Gigliucci, Grainne O’Dowd, S. Casey, Danielle L. Egan, Sinead M. Gibney, Andrew Harkin
  • Psychology, Medicine
  • Psychopharmacology
  • 2013 (First Publication: 1 July 2013)
  • RationaleBehavioural antidepressant-like effects of ketamine have been reported in the forced swimming test (FST). The mechanisms mediating such effects are unknown.ObjectivesAs serotonin (5-HT) isContinue Reading
  • Andrew Harkin, Thomas J. Connor, Mark P Burns, John P. Kelly
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • 2004 (First Publication: 1 August 2004)
  • The problem of antidepressant-resistant depression has necessitated finding ways of augmenting the actions of currently existing antidepressants. The present studies investigate the possibility ofContinue Reading
  • Thomas J. Connor, Padraig Kelliher, Andrew Harkin, John P. Kelly, Brian E. Leonard
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • 1999 (First Publication: 1 September 1999)
  • The forced swim test is a behavioural paradigm that is predicative of antidepressant activity in rodents. Until recently, research has focused on the ability of antidepressant drugs to decreaseContinue Reading
  • Thomas J. Connor, Andrew Harkin, John P. Kelly, Brian E. Leonard
  • Biology, Medicine
  • Neuroimmunomodulation
  • 1999
  • The olfactory bulbectomized (OB) rat has been developed as an animal model of depression and exhibits several behavioural and neurochemical characteristics that are qualitatively similar to thoseContinue Reading