• Publications
  • Influence
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
TLDR
Findings reveal an important role for specific miRNAs in the control of hypertrophic growth and chamber remodeling of the heart in response to pathological signaling and point to mi RNAs as potential therapeutic targets in heart disease.
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
TLDR
It is shown that a small noncoding RNA that is selectively expressed in skeletal muscle, miR-206, senses motor neuron injury or loss and helps ameliorate resultant muscle damage by promoting regeneration of neuromuscular synapses and slows disease progression in ALS.
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.
TLDR
Findings point to these miRNAs as critical components of an SRF-dependent myogenic transcriptional circuit in orchestrating cardiac development, gene expression, and function.
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
TLDR
Findings reveal a common architecture of regulatory elements associated with the miR-1/-133 genes and underscore the central role of MEF2 as a regulator of the transcriptional and posttranscriptional pathways that control cardiac and skeletal muscle development.
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.
TLDR
It is found that skeletal muscle-specific microRNA miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis.
Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*
TLDR
Findings identify miR-378 and miR* as integral components of a regulatory circuit that functions under conditions of metabolic stress to control systemic energy homeostasis and the overall oxidative capacity of insulin target tissues and potential targets for pharmacologic intervention in obesity and metabolic syndrome.
Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
TLDR
It is reported that this sorting motif binds specifically to the small GTPase ARF4, a member of the ARF family of membrane budding and protein sorting regulators, which was essential for the generation of post-Golgi carriers targeted to the rod outer segments of retinal photoreceptors.
Carrion Beetles (Coleoptera: Silphidae) of Wisconsin
TLDR
The first comprehensive faunal survey of the carrion beetles of Wisconsin is presented, finding six genera and 14 species, including a new state record, Heterosilpha ramosa (Say), to improve the knowledge of Wisconsin’s Silphidae by providing distributional, temporal, and habitat information specific to Wisconsin.
...
1
2
3
4
...