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Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans
TLDR
An inhibitor of intestinal NHE3 reduces absorption of dietary sodium in rats and humans and prevents salt-induced cardiorenal injury in nephrectomized rats and suggests that therapeutic alteration of sodium transport in the gastrointestinal tract instead of the kidney could lead to improved sodium management in renal disease.
Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue.
TLDR
By combining 2 enzymes with gastric activity and complementary substrate specificity, it should be possible to increase the safe threshold of ingested gluten, thereby ameliorating the burden of a highly restricted diet for patients with celiac sprue.
Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.
TLDR
It is indicated that tenapanor is an effective inhibitor of dietary phosphorus absorption and a new approach to phosphate management in renal disease and associated mineral disorders is suggested.
Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials
TLDR
ALV003 is an orally active protease that appears to be stable in the fed stomach and degrades dietary gluten in this compartment and is well tolerated, and no serious adverse events or allergic reactions were observed.
Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.
Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
TLDR
A series of gut-restricted TGR5 agonists that elicit a potent response in mice, with minimal gallbladder-related effects are described, a compound with minimal systemic availability that may have therapeutic value to patients with type 2 diabetes mellitus, nonalcoholic steatohepatitis, or inflammatory bowel disease.
Pharmacologic inhibition of intestinal sodium uptake: a gut centric approach to sodium management
TLDR
Pharmacologic inhibition of gut NHE3 may be a viable strategy for managing sodium load in patients with CKD or with sodium-sensitive hypertension in general.
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