Andrew G. Richardson

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Human nerve fibers exhibit a distinct pattern of threshold fluctuation following a single action potential known as the recovery cycle. We developed geometrically and electrically accurate models of mammalian motor nerve fibers to gain insight into the biophysical mechanisms that underlie the changes in axonal excitability and regulate the recovery cycle.(More)
Although multiple lines of evidence implicate the primary motor cortex (M1) in motor learning, the precise role of M1 in the adaptation to novel movement dynamics and in the subsequent consolidation of a memory of those dynamics remains unclear. Here we used repetitive transcranial magnetic stimulation (rTMS) to dissociate the contribution of M1 to these(More)
It is often assumed that learning takes place by changing an otherwise stable neural representation. To test this assumption, we studied changes in the directional tuning of primate motor cortical neurons during reaching movements performed in familiar and novel environments. During the familiar task, tuning curves exhibited slow random drift. During(More)
Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inaccessibility of the brain. An approach that integrates the advantages of both techniques could provide(More)
Zhiping P. Pang,1* Ok-Ho Shin,1* Alexander C. Meyer,4* Christian Rosenmund,4,5 and Thomas C. Südhof1,2,3 1Center for Basic Neuroscience, 2Department of Molecular Genetics, and 3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, 4Department of Membrane Biophysics, Max Planck Institute for Biophysical(More)
Humans adaptively control reaching movements to maintain good performance in the presence of novel forces acting on the arm. A recent study suggested that motor memories of different force conditions are not transformed from fragile to stable states, but rather are always vulnerable to interference from newly learned conditions (Caithness et al., 2004).(More)
The Neurochip-2 is a second generation, battery-powered device for neural recording and stimulating that is small enough to be carried in a chamber on a monkey's head. It has three recording channels, with user-adjustable gains, filters, and sampling rates, that can be optimized for recording single unit activity, local field potentials,(More)
Electrocorticography (ECoG) implants have recently demonstrated promising results towards potential use in braincomputer interfaces (BCIs). Spectral changes in ECoG signals can provide insight on functional mapping of sensorimotor cortex. We present a 6.4 W electrocorticography (ECoG)/electroencephalography (EEG) processing integrated circuit (EPIC) with(More)
Neurons in the cingulate motor areas (CMA) have been shown to be involved in many aspects of sensorimotor behavior, although their role in motor learning has received less attention. Here, we recorded single-cell activity in the CMA of monkeys while they adapted reaching movements to different dynamic environments. Specifically, we analyzed CMA activity(More)
In this paper, a general purpose wireless Brain-Machine-Brain Interface (BMBI) system is presented. The system integrates four battery-powered wireless devices for the implementation of a closed-loop sensorimotor neural interface, including a neural signal analyzer, a neural stimulator, a body-area sensor node and a graphic user interface implemented on the(More)