Andrew G. Howe

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The hippocampus is needed for at least one kind of trace classical conditioning, the air-puff eye-blink paradigm. A simple model of region CA3 predicts three basic, quantitative observations of the learning behavior of rabbits. One particular quantified prediction is the learnable trace interval. The boundary region of the reliably learnable trace interval(More)
Cognitive impairments are central to schizophrenia and could mark underlying biological dysfunction but efforts to detect genetic associations for schizophrenia or cognitive phenotypes have been disappointing. Phenomics strategies emphasizing simultaneous study of multiple phenotypes across biological scales might help, particularly if the high(More)
Systematic efforts are underway to address major flaws in the current diagnostic taxonomy of mental disorders, fostering hope that a new nosology might be based on brain biology. The National Institute of Mental Health Research Domains Criteria (RDoC) initiative aims to redefine mental illness leveraging information that spans molecular to behavioral levels(More)
Quantifying the performance of a cognitive­behavioral model on a temporal paradigm requires mapping time onto the computational cycles of the simulation. We present a family of four minimal models of the hippocampus CA­3 simulated at different time resolutions. Behavioral results from the hippocampally­dependent trace classical conditioning paradigm show(More)
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