Andrew G. Howe

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The hippocampus is needed for at least one kind of trace classical conditioning, the air-puff eye-blink paradigm. A simple model of region CA3 predicts three basic, quantitative observations of the learning behavior of rabbits. One particular quantified prediction is the learnable trace interval. The boundary region of the reliably learnable trace interval(More)
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20+/-5% at 100microM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent(More)
Cognitive impairments are central to schizophrenia and could mark underlying biological dysfunction but efforts to detect genetic associations for schizophrenia or cognitive phenotypes have been disappointing. Phenomics strategies emphasizing simultaneous study of multiple phenotypes across biological scales might help, particularly if the high(More)
Systematic efforts are underway to address major flaws in the current diagnostic taxonomy of mental disorders, fostering hope that a new nosology might be based on brain biology. The National Institute of Mental Health Research Domains Criteria (RDoC) initiative aims to redefine mental illness leveraging information that spans molecular to behavioral levels(More)
The effect on the rate of reaction of each of a series of Menschutkin processes on changing from a molecular solvent to an ionic liquid was investigated. In each case, the rate acceleration observed at room temperature could be attributed to the change in the entropy of the system on reaching the transition state, offsetting any enthalpic cost.
Quantifying the performance of a cognitivebehavioral model on a temporal paradigm requires mapping time onto the computational cycles of the simulation. We present a family of four minimal models of the hippocampus CA-3 simulated at different time resolutions. Behavioral results from the hippocampally-dependent trace classical conditioning paradigm show(More)
(79)Br NMR spectroscopy has been used to monitor a series of reactions in which the bromide ion is produced, including the Menschutkin reaction of pyridine with a range of substituted benzyl bromides and a Heck coupling process. In cases where the process could also be monitored using (1)H NMR spectroscopy, the kinetic analyses using heteronuclear magnetic(More)
Quantifying the performance of a cognitive­behavioral model on a temporal paradigm requires mapping time onto the computational cycles of the simulation. We present a family of four minimal models of the hippocampus CA­3 simulated at different time resolutions. Behavioral results from the hippocampally­dependent trace classical conditioning paradigm show(More)
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