Andrew G. Howe

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The hippocampus is needed for at least one kind of trace classical conditioning, the air-puff eye-blink paradigm. A simple model of region CA3 predicts three basic, quantitative observations of the learning behavior of rabbits. One particular quantified prediction is the learnable trace interval. The boundary region of the reliably learnable trace interval(More)
Cognitive impairments are central to schizophrenia and could mark underlying biological dysfunction but efforts to detect genetic associations for schizophrenia or cognitive phenotypes have been disappointing. Phenomics strategies emphasizing simultaneous study of multiple phenotypes across biological scales might help, particularly if the high(More)
Systematic efforts are underway to address major flaws in the current diagnostic taxonomy of mental disorders, fostering hope that a new nosology might be based on brain biology. The National Institute of Mental Health Research Domains Criteria (RDoC) initiative aims to redefine mental illness leveraging information that spans molecular to behavioral levels(More)
Phosphatidylcholine (PtdCho) is the major phospholipid present in eukaryotic cell membranes generally comprising 50% of the phospholipid mass of most cells and their requisite organelles. PtdCho has a major structural role in maintaining cell and organelle integrity, and thus its synthesis must be tightly monitored to ensure appropriate PtdCho levels are(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) exacerbations are associated with declining lung function and health-related quality of life, and increased hospitalization and mortality. Clinical trials often poorly represent the elderly and thus have only partial applicability to their clinical care. OBJECTIVE To compare exacerbations,(More)
Quantifying the performance of a cognitive­behavioral model on a temporal paradigm requires mapping time onto the computational cycles of the simulation. We present a family of four minimal models of the hippocampus CA­3 simulated at different time resolutions. Behavioral results from the hippocampally­dependent trace classical conditioning paradigm show(More)
Hypermobility of the temporomandibular joint is often caused by trauma, by opening the mouth too wide, by having a mouth forced open during general anesthesia procedures, or by dental procedures. The capsule may be stretched to an extent that dislocation occurs more easily thereafter. An implant of Vitallium mesh attached to the zygoma to restrict anterior(More)
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