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SmartFrog is a framework for creating configuration-driven systems. It has been designed with the express purpose of making the design, deployment and management of distributed component-based systems simpler and more robust. Over the last decade it has been the focus for ongoing research into aspects of configuration management and large-scale distributed(More)
Cloud computing infrastructure services enable the flexible creation of virtual infrastructures on-demand. However, the creation of infrastructures is only a part of the process for provisioning services. Other steps such as installation, deployment, configuration, monitoring and management of software components are needed to fully provide services to(More)
Toxoplasma gondii has a largely clonal population in North America and Europe, with types I, II and III clonal lineages accounting for the majority of strains isolated from patients. RH, a particular type I strain, is most frequently used to characterize Toxoplasma biology. However, compared to other type I strains, RH has unique characteristics such as(More)
Next generation sequencing is helping to overcome limitations in organisms less accessible to classical or reverse genetic methods by facilitating whole genome mutational analysis studies. One traditionally intractable group, the Apicomplexa, contains several important pathogenic protozoan parasites, including the Plasmodium species that cause malaria. Here(More)
The simultaneous targeting of host and pathogen processes represents an untapped approach for the treatment of intracellular infections. Hypoxia-inducible factor-1 (HIF-1) is a host cell transcription factor that is activated by and required for the growth of the intracellular protozoan parasite Toxoplasma gondii at physiological oxygen levels. Parasite(More)
Deidentified newborn screening bloodspot samples (NBS) represent a valuable potential resource for genomic research if impediments to whole exome sequencing of NBS deoxyribonucleic acid (DNA), including the small amount of genomic DNA in NBS material, can be overcome. For instance, genomic analysis of NBS could be used to define allele frequencies of(More)
<i>Cloud Computing</i> is an innovative computing proposal, which key feature is the ease and effectiveness of providing a service. There are a number of challenges that a management system for the Cloud will need to address including: scale, reliability (fault-handling and high availability), security and service heterogeneity, to achieve effectiveness. (More)
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