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We have briefly reviewed the methods currently available for QTL analysis in segregating populations and summarized some of the conclusions arising from such analyses in plant populations. We show that the analytical methods locate QTL with poor precision (10-30 cM), unless the heritability of an individual QTL is high. Also the estimates of the QTL(More)
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 regulates CCL2 gene expression. In the following(More)
OBJECTIVE A laboratory-based program is described that assists physicians and their patients with diabetes in meeting Canadian Diabetes Association (CDA) practice recommendations for laboratory testing. The program also supports self-management of diabetes by providing laboratory results directly to patients as well as their physicians. METHODS The(More)
The possible role of fibrin deposition in the development of diabetic glomerulosclerosis has been investigated by light, immunofluorescence, and electron microscopy examination of renal tissue obtained by percutaneous biopsy from seven diabetic patients having minimal clinical evidence of renal involvement and at necropsy on nine diabetic patients. Although(More)
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