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PURPOSE Triple-negative (TN; estrogen receptor, progesterone receptor, and HER-2 negative) cancer and basal-like breast cancer (BLBC) are associated with poor outcome and lack the benefit of targeted therapy. It is widely perceived that BLBC and TN tumors are synonymous and BLBC can be defined using a TN definition without the need for the expression of(More)
Current research examining the potential of the World-Wide Web as a means of increasing public participation in local environmental decision making in the UK is discussed. The paper considers traditional methods of public participation and argues that new Internet-based technologies have the potential to widen participation in the UK planning system.(More)
Shear wave elastography is a new method of obtaining quantitative tissue elasticity data during breast ultrasound examinations. The aims of this study were (1) to determine the reproducibility of shear wave elastography (2) to correlate the elasticity values of a series of solid breast masses with histological findings and (3) to compare shear wave(More)
In this paper we describe the development of Internet-based approaches to public participation and on-line spatial decision support systems in particular. Two case studies in developing web-based public participation GIS (PPGIS), one local and one regional, are described in detail. Results from the live testing of these systems are shown. These are(More)
BACKGROUND Percutaneous needle core biopsy has become established in the management of small renal masses ≤ 4 cm (SRMs). Recent series have reported success rates of ≥ 80%. Nondiagnostic results continue to be problematic. OBJECTIVE To determine the results of SRM biopsy and the outcomes of nondiagnostic biopsy and repeat biopsy. DESIGN, SETTING, AND(More)
We examined whether selected polymorphisms in 11 candidate genes and serum levels of insulin-like growth factor I (IGF-I) help predict the presence of prostate cancer among patients prescreened with prostate-specific antigen (PSA) and digital rectal exam (DRE). We studied 1031 consecutive men who underwent one or more prostate biopsies because of an(More)
BACKGROUND Brachytherapy, active surveillance, and watchful waiting are increasingly being offered to men with low-risk prostate cancer. However, many of these men harbor undetected high-grade disease (Gleason pattern > or =4). The ability to identify those individuals with occult high-grade disease may help guide treatment decisions in this patient cohort.(More)
OBJECTIVE • To investigate androgen receptor (AR) expression in a large series of patients with bladder cancer (BC) because data on a limited number of patients showed that loss of AR expression was associated with invasive BC. PATIENTS AND METHODS • A total of 472 patients with urothelial bladder carcinoma (UBC) from two institutional centres (Toronto(More)
Median survival from liver metastases secondary to breast cancer is only a few months, with very rare 5-year survival. This study reviewed 145 patients with liver metastases from breast cancer to determine factors that may influence survival. Data were analysed using Kaplan-Meier survival curves, univariate and multivariate analysis. Median survival was(More)
BACKGROUND Accurate localization of impalpable breast lesions that require biopsy is important. This randomized trial compared radioisotope occult lesion localization (ROLL) with the standard hooked-wire technique. METHODS Ninety-five patients were randomized to receive either ROLL or wire localization of an occult breast lesion. Correct placement of(More)