Andrew E. Davis

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Integrin-signaling complexes play important roles in cytoskeletal organization and cell adhesion in many species. Components of the integrin-signaling complex have been linked to aging in both Caenorhabditis elegans and Drosophila melanogaster, but the mechanism underlying this function is unknown. Here, we investigated the role of integrin-linked kinase(More)
Dietary restriction (DR) is a dietary regimen that extends lifespan in many organisms. One mechanism contributing to the conserved effect of DR on longevity is the cellular recycling process autophagy, which is induced in response to nutrient scarcity and increases sequestration of cytosolic material into double-membrane autophagosomes for degradation in(More)
Fig 1A is incorrectly cited instead of Fig 2A in the subsection 'The intestine of eat-2 mutants contains an enlarged acidic compartment and displays accelerated autophagosome turnover' of the Results section. The sentence 'RNAi from the L4 larval stage to Day 4 of adulthood caused a ~4-fold accumulation of GFP::LGG-1 punctae in the intestine of(More)
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