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BACKGROUND Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of clinical information and biosamples for research. METHODS We report(More)
Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for(More)
The computer self test (CST) is an interactive, internet-based instrument designed to assess functional cognitive domains impaired by Alzheimer's disease (AD) and mild cognitive impairment (MCI). This study consisted of 215 total subjects with a mean age of 75.24. The 84 cognitively impaired patients (excluding patients diagnosed as MCI) met all criteria(More)
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European(More)
We numerically analyze the possibility of turning off post-smoothing (relaxation) in geometric multigrid when used as a preconditioner in conjugate gradient linear and eigenvalue solvers for the 3D Laplacian. The geometric Semicoarsen-ing Multigrid (SMG) method is provided by the hypre parallel software package. We solve linear systems using two variants(More)
We report detailed shape measurements of the tips of three-dimensional NH 4 Cl dendrites grown from supersaturated aqueous solution. For growth at small super-saturation, we compare two models for the tip shape: parabolic with a fourth-order correction and a power law. Neither is ideal, but the fourth-order fit appears to provide the most robust description(More)
We aimed to assess whether rural residence is associated with amyotrophic lateral sclerosis in the south-east of England using a population based register. Previous studies in different populations have produced contradictory findings. Residence defined by London borough or non-metropolitan district at time of diagnosis was recorded for each incident case(More)
We report measurements of the initial growth and subsequent transient response of dendritic crystals of ammonium chloride grown from supersaturated aqueous solution. Starting from a small, nearly spherical seed held in unstable equilibrium, we lower the temperature to initiate growth. The growth speed and tip radius approach the same steady state values(More)
We analyze a possibility of turning off post-smoothing (relaxation) in geometric multigrid when used as a preconditioner in preconditioned conjugate gradient (PCG) linear and eigen-value solvers for the 3D Laplacian. The geometric Semicoarsening Multigrid (SMG) method is provided by the hypre parallel software package. We solve linear systems using two(More)
  • H Bouwmeester, A Dougherty, A V Knyazev, Henricus Bouwmeester, Andrew Dougherty, Andrew V Knyazev
  • 2013
We numerically analyze the possibility of turning off post-smoothing (relaxation) in geometric multigrid when used as a preconditioner in conjugate gradient linear and eigenvalue solvers for the 3D Laplacian. The geometric Semicoarsening Multigrid (SMG) method is provided by the hypre parallel software package. We solve linear systems using two variants(More)