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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

• Timothy M. Frayling, Nicholas J. Timpson, +38 authors Mark I. McCarthy
• Science
• 2007

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type… (More)

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

• Josée Dupuis, Claudia Langenberg, +300 authors Inês Barroso
• Nature Genetics
• 2010

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting… (More)

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

• Eleftheria Zeggini, Laura J. Scott, +95 authors David Altshuler
• Nature Genetics
• 2008

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and… (More)

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

• Benjamin F. Voight, Laura J. Scott, +155 authors Mark I. McCarthy
• Nature Genetics
• 2010

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a… (More)

Genetic studies of body mass index yield new insights for obesity biology

• Adam E Locke, Bratati Kahali, +478 authors Elizabeth K. Speliotes
• Nature
• 2015

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… (More)

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

• Eleftheria Zeggini, M. N. Weedon, +23 authors Andrew T Hattersley
• Science
• 2007

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated… (More)

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

• Andrew P. Morris, Benjamin F. Voight, +201 authors Mark I. McCarthy
• Nature Genetics
• 2012

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… (More)

Discovery and Refinement of Loci Associated with Lipid Levels

• Cristen J. Willer, Ellen M. Schmidt, +256 authors Gonçalo R. Abecasis
• Nature Genetics
• 2013

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… (More)

Common variants near MC4R are associated with fat mass, weight and risk of obesity

• Ruth J. F. Loos, Cecilia M. Lindgren, +98 authors Inês Barroso
• Nature Genetics
• 2008

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the… (More)

Large-scale association analysis identifies new risk loci for coronary artery disease

• Panos Deloukas, Stavroula Kanoni, +180 authors Nilesh J. Samani
• Nature Genetics
• 2013

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance,… (More)

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