• Publications
  • Influence
Endocannabinoid signalling modulates susceptibility to traumatic stress exposure
Stress is a ubiquitous risk factor for the exacerbation and development of affective disorders including major depression and posttraumatic stress disorder. Understanding the neurobiologicalExpand
  • 54
  • 5
Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors
Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models. Pharmacological inhibition ofExpand
  • 37
  • 3
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety
BACKGROUND Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB)Expand
  • 40
  • 2
Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain.
Cyclooxygenase-2 (COX-2) catalyzes the formation of prostaglandins, which are involved in immune regulation, vascular function, and synaptic signaling. COX-2 also inactivates the endogenousExpand
  • 12
  • 1
Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening
Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the mechanisms by which stressExpand
  • 17
  • 1
Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice
Elucidating the underlying molecular mechanisms regulating fear and extinction learning may offer insights that can lead to novel treatments for debilitating anxiety and trauma-related disordersExpand
  • 12
  • 1
  • PDF
Dynamic remodeling of a basolateral to central amygdala glutamatergic circuit across fear states
Acquisition and extinction of learned fear responses utilize conserved but flexible neural circuits. Here we show that acquisition of conditioned freezing behavior is associated with dynamicExpand
  • 11
Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior
Stress is a major risk factor for the development and exacerbation of mood and anxiety disorders, and recent studies have suggested inflammatory contributions to the pathogenesis of depression.Expand