We constructed a bacterial artificial chromosome (BAC)-based physical map of chromosomes 2 and 3 of Drosophila melanogaster, which constitute 81% of the genome. Sequence tagged site (STS) content, restriction fingerprinting, and polytene chromosome in situ hybridization approaches were integrated to produce a map spanning the euchromatin. Three of five… (More)
Information Integrator is an extension to IBM's relational database DB2, which uses data federation to provide benefits to molecular biology researchers through two unique capabilities: increased flexibility in combining data from disparate sources, and SQL access to non-SQL data, easing the task of automating data analysis.
The revolution in life sciences research brought about by the sequencing of the human genome creates new challenges for scientists and new opportunities for computing support organizations. This may involve significant shifts in computing support strategies, particularly as regards interacting with life sciences researchers who maintain a medical practice.… (More)
We implemented a distributed system for management of data for an international collaboration studying Fetal Alcohol Spectrum Disorders (FASD). Subject privacy was protected, researchers without dependable Internet access were accommodated, and researchers' data were shared globally. Data dictionaries codified the nature of the data being integrated, data… (More)